2025
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Belabed M, Park M, Blouin C, Balan S, Moon C, Freed G, Quijada-Álamo M, Peros A, Mattiuz R, Reid A, Yatim N, Boumelha J, Azimi C, LaMarche N, Troncoso L, Amabile A, Le Berichel J, Chen S, Wilk C, Brown B, Radford K, Ghosh S, Rothlin C, Yvan-Charvet L, Marron T, Puleston D, Wagenblast E, Bhardwaj N, Lamaze C, Merad M. Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer. Nature Immunology 2025, 26: 188-199. PMID: 39838105, DOI: 10.1038/s41590-024-02065-8.Peer-Reviewed Original ResearchConventional dendritic cellsNiemann-Pick disease type C1Maturation of conventional dendritic cellsExpression of maturation markersCholesterol mobilizationAnti-tumor immunityReceptor tyrosine kinase AXLDendritic cell maturationResponse to cancerTyrosine kinase AXLDendritic cellsImmune receptor signalingMaturation markersAuto-immunityCell maturationReceptor signalingImmunogenic responseTherapeutic targetCholesterol transportLipid nanodomainsSubcellular mechanismsCholesterolType C1CancerCell surface
2024
New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis
Carrera Silva E, Correale J, Rothlin C, Ortiz Wilczyñski J. New potential ligand-receptor axis involved in tissue repair as therapeutic targets in progressive multiple sclerosis. Journal Of Pharmacology And Experimental Therapeutics 2024, 392: 100029. PMID: 39892997, DOI: 10.1124/jpet.124.002254.Peer-Reviewed Original ResearchProgressive multiple sclerosisLigand-receptor axisNeuroprotective therapeutic strategiesMultiple sclerosisTissue repairTherapeutic strategiesRefractory to current treatmentsIncreasing preclinical evidenceStages of multiple sclerosisEarly stages of multiple sclerosisAnti-inflammatoryPromote tissue repairTissue repair processPreclinical evidenceTherapeutic optionsReceptor axisReceptor/ligand pairsCurrent treatmentPathogenic mechanismsMS diseaseBenefit patientsTherapeutic interventionsTherapeutic targetSignaling axisEra of omics
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