2024
Bending stiffness of Toxoplasma gondii actin filaments
Cao W, Sladewski T, Heaslip A, De La Cruz E. Bending stiffness of Toxoplasma gondii actin filaments. Journal Of Biological Chemistry 2024, 301: 108101. PMID: 39706262, PMCID: PMC11786770, DOI: 10.1016/j.jbc.2024.108101.Peer-Reviewed Original ResearchConceptsActin filamentsD-loopMechanical properties of actin filamentsFilament subunitsSkeletal muscle actin filamentsProperties of actin filamentsSkeletal muscle actinMuscle actin filamentsFilament length distributionApicomplexan parasite Toxoplasma gondiiIntersubunit salt bridgesOrganelle inheritancePointed-endSubunit interactionsNeighboring subunitUnique assembly propertiesSalt bridgesSubunitFunctional consequencesSubunit dissociationVisible densityActinSubunit incorporationParasite Toxoplasma gondiiFilamentsToxoplasma gondii actin filaments are tuned for rapid disassembly and turnover
Hvorecny K, Sladewski T, De La Cruz E, Kollman J, Heaslip A. Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover. Nature Communications 2024, 15: 1840. PMID: 38418447, PMCID: PMC10902351, DOI: 10.1038/s41467-024-46111-3.Peer-Reviewed Original ResearchConceptsActin filamentsDynamic properties of actin filamentsProperties of actin filamentsCytoskeletal protein actinFilamentous actin networkSkeletal muscle actinCryo-EM structureIn vitro assemblyOrganelle inheritanceD-loopActin networkNucleotide exchangeLive cell imagingProteins actinSkeletal actinConserved structureEvolutionary changesActinApicomplexan parasitesAssembly contactsIntracellular parasitesMonomer dissociationApicomplexanFilamentsBiophysical properties
2016
Cations Stiffen Actin Filaments by Adhering a Key Structural Element to Adjacent Subunits
Hocky GM, Baker JL, Bradley MJ, Sinitskiy AV, De La Cruz EM, Voth GA. Cations Stiffen Actin Filaments by Adhering a Key Structural Element to Adjacent Subunits. The Journal Of Physical Chemistry B 2016, 120: 4558-4567. PMID: 27146246, PMCID: PMC4959277, DOI: 10.1021/acs.jpcb.6b02741.Peer-Reviewed Original ResearchConceptsActin filamentsRegulatory proteinsD-loopSite-specific mutagenesisSpecific divalent cationsFilament severingStructural bioinformaticsAdjacent subunitsAccessible conformational spaceSubunit conformationActin subunitsKey structural elementsAmino acidsLarge-scale changesConformational spaceSubunitsFilament mechanical propertiesProteinFilamentsDivalent cationsMagnesium ionsMolecular dynamics simulationsConformationSitesCofilin
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