2024
Evolutionary innovations in germline biology of placental mammals identified by transcriptomics of first-wave spermatogenesis in opossum
Marshall K, Stadtmauer D, Maziarz J, Wagner G, Lesch B. Evolutionary innovations in germline biology of placental mammals identified by transcriptomics of first-wave spermatogenesis in opossum. Developmental Cell 2024 PMID: 39536760, DOI: 10.1016/j.devcel.2024.10.013.Peer-Reviewed Original ResearchPlacental mammalsLevel of transcriptionSingle-cell dataGene expression patternsMammalian spermatogenesisGene expression programsEpigenomic dataAdult testisEvolutionary innovationSpermatogenic cellsGene setsSpermatogenic developmentModel marsupialOpossum Monodelphis domesticaGene expressionExpression patternsGenesDevelopmental processesExpression programsSpermatogenesisMonodelphis domesticaMammalsDevelopmental timeCombination of featuresExpression
2023
Normalizing need not be the norm: count-based math for analyzing single-cell data
Church S, Mah J, Wagner G, Dunn C. Normalizing need not be the norm: count-based math for analyzing single-cell data. Theory In Biosciences 2023, 143: 45-62. PMID: 37947999, DOI: 10.1007/s12064-023-00408-x.Peer-Reviewed Original Research
2013
Gene expression in the term placenta of the opossum Monodelphis domestica and the evolution of the therian placenta
McGowen M, Weckle A, Agnew D, Benirschke K, Savage-Rumbaugh S, Kim C, Wagner G, Romero R, Wildman D. Gene expression in the term placenta of the opossum Monodelphis domestica and the evolution of the therian placenta. Placenta 2013, 34: a24-a25. DOI: 10.1016/j.placenta.2013.06.075.Peer-Reviewed Original Research
2008
Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals
Lynch VJ, Tanzer A, Wang Y, Leung FC, Gellersen B, Emera D, Wagner GP. Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14928-14933. PMID: 18809929, PMCID: PMC2567470, DOI: 10.1073/pnas.0802355105.Peer-Reviewed Original ResearchConceptsCis-regulatory elementsHoxa-11Evolutionary changePlacental mammalsEutherian mammalsTranscription factorsCis-regulatory evolutionDirect regulatory targetsGene expression domainsStrong positive selectionNovel developmental pathwayPRL expressionTherian ancestorGene regulationExpression domainsPositive selectionRegulatory targetsNovel functionDevelopmental pathwaysMammalsSpatial expressionProlactin expressionGenesExpressionAdaptive changes
2001
The tetrapod limb: A hypothesis on its origin
Wagner G, Chiu C. The tetrapod limb: A hypothesis on its origin. Journal Of Experimental Zoology 2001, 291: 226-240. PMID: 11598912, DOI: 10.1002/jez.1100.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTetrapod limbsExpression domainsHoxa-13Hoxa-11Fin-limb transitionExclusive expression domainsMajor morphological adaptationsProximal-distal axisVertebrate evolutionFin developmentHoxa-11 expressionTerrestrial lifestyleFin skeletonMorphological adaptationsDevelopmental mechanismsExpression patternsLimb budPaleontological evidenceGenetic hypothesisExpressionZebrafishEvolutionHomologyAquaticGenes
1999
Is Hsp90 a regulator of evolvability?
Wagner G, Chiu C, Hansen T. Is Hsp90 a regulator of evolvability? Journal Of Experimental Zoology 1999, 285: 116-118. PMID: 10440722, DOI: 10.1002/(sici)1097-010x(19990815)285:2<116::aid-jez3>3.0.co;2-p.Commentaries, Editorials and Letters
1984
On the eigenvalue distribution of genetic and phenotypic dispersion matrices: Evidence for a nonrandom organization of quantitative character variation
Wagner G. On the eigenvalue distribution of genetic and phenotypic dispersion matrices: Evidence for a nonrandom organization of quantitative character variation. Journal Of Mathematical Biology 1984, 21: 77-95. DOI: 10.1007/bf00275224.Peer-Reviewed Original ResearchQuantitative genetic variationQuantitative genetic modelGenetic variationInsect dataCharacter variationNonrandom organizationPleiotropy modelUnrelated charactersGenetic modelsPleiotropyRandom matricesEigenvalue distributionDispersion matrixRandom organizationGaussian random matricesCorrelation matrix REmpirical correlation matrixInsectsEigenvalue densityIntermediate eigenvaluesMatrix GMatrix RDensity functionExpressionApproximate expression
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