Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction
Zhang S, Paccalet A, Rohde D, Cremer S, Hulsmans M, Lee I, Mentkowski K, Grune J, Schloss M, Honold L, Iwamoto Y, Zheng Y, Bredella M, Buckless C, Ghoshhajra B, Thondapu V, van der Laan A, Piek J, Niessen H, Pallante F, Carnevale R, Perrotta S, Carnevale D, Iborra-Egea O, Muñoz-Guijosa C, Galvez-Monton C, Bayes-Genis A, Vidoudez C, Trauger S, Scadden D, Swirski F, Moskowitz M, Naxerova K, Nahrendorf M. Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction. Nature Cardiovascular Research 2023, 2: 1277-1290. PMID: 38344689, PMCID: PMC10857823, DOI: 10.1038/s44161-023-00388-7.Peer-Reviewed Original ResearchMyocardial infarctionFatty acid metabolismHematopoietic stem cell homeostasisEmergency hematopoiesisStem cell homeostasisAcid metabolismHematopoietic progenitor proliferationBone marrow adipocytesInflammatory myeloid cellsMyeloid cell expansionHematopoietic progenitor cellsBone marrow adiposityMitochondrial metabolismMetabolic cuesFatty acid oxidationCell homeostasisProgenitor proliferationHematopoietic cellsMarrow adipocytesAdipocyte shrinkageRegional sympathectomyHeart failureCell expansionFl miceProgenitor cells
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