Conjugation of Listeriolysin O to Anti-CD47 mAb: Harnessing Listeria Toxin to Weaponize Macrophages against Tumor Cells
Schrank B, Wang Y, Jiang W. Conjugation of Listeriolysin O to Anti-CD47 mAb: Harnessing Listeria Toxin to Weaponize Macrophages against Tumor Cells. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: s42. DOI: 10.1016/j.ijrobp.2022.07.408.Peer-Reviewed Original ResearchAnti-CD47 mAbBone marrow-derived macrophagesTumor cell phagocytosisMarrow-derived macrophagesAntigen presentationTumor cellsIntratumoral injectionWildtype miceCGAS-STING activationCell phagocytosisNon-Hodgkin's lymphomaCell line MDA-MB-468Hematopoietic tumor cellsMonocytic cell line THP-1Treatment of malignanciesMouse bone marrow-derived macrophagesBreast cancer cell line MDA-MB-468Cell line THP-1Suppressed tumor growthListeriolysin O toxinMacrophage-mediated phagocytosisBlood cell countHuman breast cancer cell line MDA-MB-468Dose-dependent mannerListeriolysin O
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