Center Publications

Publication Acknowledgment

To cite the Liver Center in your publications please use the following statement:

”This project was supported in part by the Yale Liver Center award NIH P30 DK034989 ________ core.”
(insert name of core(s) that you used-Morphology, Cellular Molecular, Clinical-Translational)

Liver Center Publications

Portal Fibrosis and the Ductular Reaction: Pathophysiological Role in the Progression of Liver Disease and Translational Opportunities.Gupta V, Sehrawat TS, Pinzani M, Strazzabosco M. Gastroenterology. 2025 Apr; 2024 Sep 7. PMID: 39251168.
Clinicopathologic features and prognosis of steatohepatitic hepatocellular carcinoma based on varying cutoffs of tumoral steatohepatitic changes.Zhang T, Niu N, Taddei T, Jain D, Zhang X. Am J Clin Pathol. 2025 Mar 8. PMID: 39418121.
Molecular MRI of T-cell immune response to cryoablation in immunologically hot vs. cold hepatocellular carcinoma.Santana JG, Shewarega A, Nam D, Duncan J, Madoff DC, Hyder F, Coman D, Chapiro J. JHEP Rep. 2025 Mar; 2024 Dec 4. PMID: 40028344.
Mortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study.Njei B, Mezzacappa C, John BV, Serper M, Kaplan DE, Taddei TH, Mahmud N. Dig Dis Sci. 2025 Feb; 2025 Jan 8. PMID: 39779587.
CFTR High Expresser BEST4+ cells are pH-sensing neuropod cells: new implications for intestinal physiology and Cystic Fibrosis disease.Dos Reis DC, Jin J, Santos A, Muiler C, Zagoren E, Donnelley M, Parsons D, Cmielewski P, Reyne N, McCarron A, Smith Z, Sumigray K, Ameen NA. bioRxiv. 2025 Jan 27; 2025 Jan 27. PMID: 39974899.
Second-Line Treatment for Patients With Primary Biliary Cholangitis: A Systematic Review With Network Meta-Analysis.Giannini EG, Pasta A, Calabrese F, Labanca S, Marenco S, Pieri G, Plaz Torres MC, Strazzabosco M. Liver Int. 2025 Jan. PMID: 39720853.
Controversies regarding albumin therapy in cirrhosis.Trebicka J, Garcia-Tsao G. Hepatology. 2025 Jan 1; 2023 Aug 7. PMID: 37540192.
Hyperactive PLCG1 drives non-canonical signaling to promote cell survival.Zeng L, Zhang X, Xiong Y, Sato K, Hajicek N, Sondek J, Su X. bioRxiv. 2024 Dec 18; 2024 Dec 18. PMID: 39763946.
Hepatic Biliary Adenofibroma: Histological Characteristics, Diagnostic Challenges, and Its Role as a Precursor to Intrahepatic Cholangiocarcinoma.Liao X, Zhang X. J Clin Transl Pathol. 2024 Oct-Dec; 2024 Dec 24. PMID: 40026322.
CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study.Wang Y, Charkoftaki G, Orlicky DJ, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson DC, Vasiliou V, Chen Y. Arch Toxicol. 2024 Oct; 2024 Aug 27. PMID: 39192018.
Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipolysis, and gluconeogenesis via CAMKII activation.LaMoia TE, Hubbard BT, Guerra MT, Nasiri A, Sakuma I, Kahn M, Zhang D, Goodman RP, Nathanson MH, Sancak Y, Perelis M, Mootha VK, Shulman GI. Cell Metab. 2024 Oct 1; 2024 Aug 16. PMID: 39153480.
RNA modifications in the progression of liver diseases: from fatty liver to cancer.Li S, Mehal WZ, Ouyang X. Sci China Life Sci. 2024 Oct; 2024 May 27. PMID: 38809498.
Automated graded prognostic assessment for patients with hepatocellular carcinoma using machine learning.Gross M, Haider SP, Ze'evi T, Huber S, Arora S, Kucukkaya AS, Iseke S, Gebauer B, Fleckenstein F, Dewey M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Oct; 2024 Mar 27. PMID: 38536464.
Prominent role of gut dysbiosis in the pathogenesis of cystic fibrosis-related liver disease in mice.Bertolini A, Nguyen M, Zehra SA, Taleb SA, Bauer-Pisani T, Palm N, Strazzabosco M, Fiorotto R. J Hepatol. 2024 Sep; 2024 Mar 28. PMID: 38554847.
Automated MRI liver segmentation for anatomical segmentation, liver volumetry, and the extraction of radiomics.Gross M, Huber S, Arora S, Ze'evi T, Haider SP, Kucukkaya AS, Iseke S, Kuhn TN, Gebauer B, Michallek F, Dewey M, Vilgrain V, Sartoris R, Ronot M, Jaffe A, Strazzabosco M, Chapiro J, Onofrey JA. Eur Radiol. 2024 Aug; 2024 Jan 13. PMID: 38217704.
Systematic Review and Meta-Analysis of Urine Neutrophil Gelatinase-Associated Lipocalin for Acute Kidney Injury in Cirrhosis.Puthumana J, Lugon NC, Xu Y, Deng Y, Mistry PK, Parikh CR. Kidney Int Rep. 2024 Jul; 2024 May 3. PMID: 39081737.
Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features.Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell MJ, Utsumi T, Pereira J, Iwakiri Y. JHEP Rep. 2024 Jul; 2024 Mar 18. PMID: 38966234.
Electrocardiographic abnormalities in patients with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis.Dimala CA, Nso N, Wasserlauf J, Njei B. Curr Probl Cardiol. 2024 Jul; 2024 Apr 21. PMID: 38653446.
MAPK Phosphatase-5 is required for TGF-β signaling through a JNK-dependent pathway.Dorry S, Perla S, Bennett AM. bioRxiv. 2024 Jun 27; 2024 Jun 27. PMID: 38979264.
Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis.Ogino N, Leite MF, Guerra MT, Kruglov E, Asashima H, Hafler DA, Ito T, Pereira JP, Peiffer BJ, Sun Z, Ehrlich BE, Nathanson MH. J Clin Invest. 2024 Jun 25; 2024 Jun 25. PMID: 38916955.
Complement Membrane Attack Complexes Disrupt Proteostasis to Function as Intracellular Alarmins.Jane-Wit D, Song G, He L, Jiang Q, Barkestani M, Wang S, Wang Q, Ren P, Fan M, Johnson J, Mullan C. Res Sq. 2024 Jun 19; 2024 Jun 19. PMID: 38947095.
Cost-effectiveness analysis: The missing factor in the management of HCC.Njei B, Yi I, Strazzabosco M. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 Jun 7. PMID: 38860130.
Safety and Efficacy of Atezolizumab/Bevacizumab in Patients with Hepatocellular Carcinoma and Impaired Liver Function: A Systematic Review and Meta-Analysis.Pasta A, Calabrese F, Jaffe A, Labanca S, Marenco S, Pieri G, Plaz Torres MC, Strazzabosco M, Giannini EG. Liver Cancer. 2024 Jun; 2023 Oct 14. PMID: 38756146.
Cardiovascular morbidity and mortality in lean vs. non-lean MASLD: A comprehensive meta-analysis.Nso N, Mergen D, Ikram M, Macrinici V, Hussain K, Lee K, Ugwendum D, Trimingham M, Balasubramanian S, Sam R, Njei B. Curr Probl Cardiol. 2024 Jun; 2024 Apr 8. PMID: 38599554.
Approach to immunotherapy for HCC in the liver transplant population.Block PD, Strazzabosco M, Jaffe A. Clin Liver Dis (Hoboken). 2024 Jan-Jun; 2024 May 3. PMID: 38707244.
An explainable machine learning model for prediction of high-risk nonalcoholic steatohepatitis.Njei B, Osta E, Njei N, Al-Ajlouni YA, Lim JK. Sci Rep. 2024 Apr 13; 2024 Apr 13. PMID: 38615137.
Feasibility of an Interprofessional Inpatient Educational Intervention for Patients With Decompensated Cirrhosis.Haque LY, McDonough M, Deng Y, Ciarleglio MM, Liapakis A, Jakab S. Gastro Hep Adv. 2024; 2024 Mar 22. PMID: 39165423.
Mechanosensing regulates tissue repair program in macrophages.Meizlish ML, Kimura Y, Pope SD, Matta R, Kim C, Philip NH, Meyaard L, Gonzalez A, Medzhitov R. Sci Adv. 2024 Mar 15; 2024 Mar 13. PMID: 38478620.
Cell surface RNAs control neutrophil recruitment.Zhang N, Tang W, Torres L, Wang X, Ajaj Y, Zhu L, Luan Y, Zhou H, Wang Y, Zhang D, Kurbatov V, Khan SA, Kumar P, Hidalgo A, Wu D, Lu J. Cell. 2024 Feb 15; 2024 Jan 22. PMID: 38262409.
Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage.Ruz-Maldonado I, Gonzalez JT, Zhang H, Sun J, Bort A, Kabir I, Kibbey RG, Suárez Y, Greif DM, Fernández-Hernando C. Nat Commun. 2024 Feb 10; 2024 Feb 10. PMID: 38341404.
Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study.Mezzacappa C, Rossi R, Jaffe A, Taddei TH, Strazzabosco M. Cancer Epidemiol Biomarkers Prev. 2024 Feb 6. PMID: 38059831.
Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8(+) T-Cell Infiltration in Murine Hepatocellular Carcinoma.Shewarega A, Santana JG, Nam D, Berz A, Tefera J, Kahl V, Mishra SK, Coman D, Duncan J, Roberts SJ, Wetter A, Madoff DC, Chapiro J. Radiology. 2024 Feb. PMID: 38349244.
Modulation of canonical Wnt signaling regulates peribiliary mesenchymal identity during homeostasis and injury.Singh S, Budiman T, Redmond D, Gupta V. Hepatol Commun. 2024 Feb 1; 2024 Jan 22. PMID: 38251878.
Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.Li X, Jiang Q, Song G, Barkestani MN, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober JS, Jane-Wit D. Nat Commun. 2023 Dec 18; 2023 Dec 18. PMID: 38110370.
HCC is associated with diabetes and longitudinal blood glucose control in a national cohort with cirrhosis.Mezzacappa C, Mahmud N, Serper M, John BV, Taddei TH, Kaplan DE. Hepatol Commun. 2023 Dec 1; 2023 Dec 7. PMID: 38055642.
Heterogeneous murine peribiliary glands orchestrate compartmentalized epithelial renewal.Singh S, Lian Q, Budiman T, Taketo MM, Simons BD, Gupta V. Dev Cell. 2023 Dec 4; 2023 Oct 30. PMID: 37909044.
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.Song J, Lv H, Liu B, Hao M, Taylor HS, Zhang X, Li D, Huang Y. Mol Metab. 2023 Dec; 2023 Oct 28. PMID: 37898449.
LiverHccSeg: A publicly available multiphasic MRI dataset with liver and HCC tumor segmentations and inter-rater agreement analysis.Gross M, Arora S, Huber S, Kücükkaya AS, Onofrey JA. Data Brief. 2023 Dec; 2023 Oct 10. PMID: 37869619.
The Sympathetic Nervous System Promotes Hepatic Lymphangiogenesis, which Is Protective Against Liver Fibrosis.Tanaka M, Jeong J, Thomas C, Zhang X, Zhang P, Saruwatari J, Kondo R, McConnell MJ, Utsumi T, Iwakiri Y. Am J Pathol. 2023 Dec; 2023 Sep 4. PMID: 37673329.
Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma.Singh AK, Chaube B, Citrin KM, Fowler JW, Lee S, Catarino J, Knight J, Lowery S, Shree S, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross TT, Malaker S, Suárez Y, Fernández-Hernando C, Grabinska K, Sessa WC. bioRxiv. 2023 Nov 15; 2023 Nov 15. PMID: 38014178.
HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis.Huang Y, Liangpunsakul S, Rudraiah S, Ma J, Keshipeddy SK, Wright D, Costa A, Burgess D, Zhang Y, Huda N, Wang L, Yang Z. Hepatol Commun. 2023 Nov 1; 2023 Nov 6. PMID: 37930124.
An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver.Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell MJ, Utsumi T, Iwakiri Y. Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1; 2023 Aug 22. PMID: 37605828.
Mitochondrial DNA and the STING pathway are required for hepatic stellate cell activation.Arumugam S, Li B, Boodapati SLT, Nathanson MH, Sun B, Ouyang X, Mehal WZ. Hepatology. 2023 Nov 1; 2023 Apr 5. PMID: 37013923.
Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease.Du Y, de Jong IEM, Gupta K, Waisbourd-Zinman O, Har-Zahav A, Soroka CJ, Boyer JL, Llewellyn J, Liu C, Naji A, Polacheck WJ, Wells RG. Biofabrication. 2023 Oct 20; 2023 Oct 20. PMID: 37820623.
DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid.Oyaghire SN, Quijano E, Perera JDR, Mandl HK, Saltzman WM, Bahal R, Glazer PM. Cell Rep Phys Sci. 2023 Oct 18. PMID: 37920723.
Hedgehog costimulation during ischemia-reperfusion injury potentiates cytokine and homing responses of CD4(+) T cells.Wang S, Song G, Barkestani MN, Tobiasova Z, Wang Q, Jiang Q, Lopez R, Adelekan-Kamara Y, Fan M, Pober JS, Tellides G, Jane-Wit D. Front Immunol. 2023; 2023 Oct 17. PMID: 37915586.
Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability.Zhang J, Wu Q, Hu X, Wang Y, Lu J, Chakraborty R, Martin KA, Guo S. Stem Cells. 2023 Oct 8. PMID: 37386941.
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis.Mooring M, Yeung GA, Luukkonen P, Liu S, Akbar MW, Zhang GJ, Balogun O, Yu X, Mo R, Nejak-Bowen K, Poyurovsky MV, Booth CJ, Konnikova L, Shulman GI, Yimlamai D. Sci Transl Med. 2023 Sep 27; 2023 Sep 27. PMID: 37756381.
Protocol for enrichment, purification, and cytocentrifugation of mouse liver endothelial cells.Chowdhury S, Fried KD, Iwakiri Y, Brancale J, Vilarinho S. STAR Protoc. 2023 Sep 15; 2023 Jul 28. PMID: 37515764.
Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia.Li X, Lozovatsky L, Tommasini SM, Fretz J, Finberg KE. Blood Adv. 2023 Sep 12. PMID: 37417950.
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.Qiu B, Lawan A, Xirouchaki CE, Yi JS, Robert M, Zhang L, Brown W, Fernández-Hernando C, Yang X, Tiganis T, Bennett AM. Nat Commun. 2023 Sep 5; 2023 Sep 5. PMID: 37669951.
Advancing diagnosis and management of liver disease in adults through exome sequencing.Zheng M, Hakim A, Konkwo C, Deaton AM, Ward LD, Silveira MG, Assis DN, Liapakis A, Jaffe A, Jiang ZG, Curry MP, Lai M, Cho MH, Dykas D, Bale A, Mistry PK, Vilarinho S. EBioMedicine. 2023 Sep; 2023 Aug 9. PMID: 37566928.
Hedgehog signalling in allograft vasculopathy: a new therapeutic target?Rowell J, Lau CI, Yánez DC, Zhang E, Crompton T. Trends Pharmacol Sci. 2023 Sep; 2023 Jun 7. PMID: 37296035.
Humanized mouse liver reveals endothelial control of essential hepatic metabolic functions.Kaffe E, Roulis M, Zhao J, Qu R, Sefik E, Mirza H, Zhou J, Zheng Y, Charkoftaki G, Vasiliou V, Vatner DF, Mehal WZ, Yuval Kluger, Flavell RA. Cell. 2023 Aug 31; 2023 Aug 9. PMID: 37562401.
The evolving role of liver sinusoidal endothelial cells in liver health and disease.McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. Hepatology. 2023 Aug 1; 2023 Jan 3. PMID: 36626620.
Acetate controls endothelial-to-mesenchymal transition.Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. Cell Metab. 2023 Jul 11; 2023 Jun 15. PMID: 37327791.
PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens.Damo M, Hornick NI, Venkat A, William I, Clulo K, Venkatesan S, He J, Fagerberg E, Loza JL, Kwok D, Tal A, Buck J, Cui C, Singh J, Damsky WE, Leventhal JS, Krishnaswamy S, Joshi NS. Nature. 2023 Jul; 2023 Jun 21. PMID: 37344588.
Above the legal limit: Alcohol brings ER and mitochondria too close together.Guerra MT, Nathanson MH. Cell Calcium. 2023 Jul; 2023 May 22. PMID: 37235972.
Update in the Treatment of the Complications of Cirrhosis.Abraldes JG, Caraceni P, Ghabril M, Garcia-Tsao G. Clin Gastroenterol Hepatol. 2023 Jul; 2023 Mar 25. PMID: 36972759.
Role of Oral Health, Frailty, and Minimal Hepatic Encephalopathy in the Risk of Hospitalization: A Prospective Multi-Center Cohort of Outpatients With Cirrhosis.Bajaj JS, Lai JC, Tandon P, O'Leary JG, Wong F, Garcia-Tsao G, Vargas HE, Kamath PS, Biggins SW, Limon-Miro A, Shaw J, Mbachi C, Chew M, Golob Deeb J, Thacker LR, Reddy KR. Clin Gastroenterol Hepatol. 2023 Jul; 2022 Nov 1. PMID: 36328307.
Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype.Davidson EA, Chen Y, Singh S, Orlicky DJ, Thompson B, Wang Y, Charkoftaki G, Furnary TA, Cardone RL, Kibbey RG, Shearn CT, Nebert DW, Thompson DC, Vasiliou V. bioRxiv. 2023 Jun 26; 2023 Jun 26. PMID: 37398356.
Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK/STAT3 signaling.Zhang L, Pan Q, Zhang L, Xia H, Liao J, Zhang X, Zhao N, Xie Q, Liao M, Tan Y, Li Q, Zhu J, Li L, Fan S, Li J, Zhang C, Cai SY, Boyer JL, Chai J. Hepatology. 2023 Jun 1; 2023 Jan 3. PMID: 36647589.
Adherence to Tumor Board Recommendations in the Treatment of Patients with Hepatocellular Carcinoma.Cao Y, Mezzacappa C, Jaffe A, Strazzabosco M, Taddei TH. J Multidiscip Healthc. 2023; 2023 May 31. PMID: 37283950.
Editorial: Rising stars in aging, metabolism and redox biology.Yang X, Zhang J. Front Aging. 2023; 2023 May 26. PMID: 37305227.
A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.Li X, Jiang Q, Song G, Barkestani MN, Wang Q, Wang S, Fan M, Fang C, Jiang B, Johnson J, Geirsson A, Tellides G, Pober JS, Jane-Wit D. Nat Commun. 2023 May 24; 2023 May 24. PMID: 37225719.
Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo.Akingbesote ND, Leitner BP, Jovin DG, Desrouleaux R, Owusu D, Zhu W, Li Z, Pollak MN, Perry RJ. Elife. 2023 May 23; 2023 May 23. PMID: 37219930.
FGF-21 Conducts a Liver-Brain-Kidney Axis to Promote Renal Cell Carcinoma.Li Z, Zhang X, Zhu W, Zhang C, Sadak K, Halberstam AA, Brown JR, Perry CJ, Bunn A, Braun DA, Adeniran A, Lee S, Wang A, Perry RJ. bioRxiv. 2023 Apr 13; 2023 Apr 13. PMID: 37090652.
Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation.Fiorotto R, Mariotti V, Taleb SA, Zehra SA, Nguyen M, Amenduni M, Strazzabosco M. Hepatol Commun. 2023 Apr 1; 2023 Mar 24. PMID: 36972396.
HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction.Subramanian K, Paul S, Libby A, Patterson J, Arterbery A, Knight J, Castaldi C, Wang G, Avitzur Y, Martinez M, Lobritto S, Deng Y, Geliang G, Kroemer A, Fishbein T, Mason A, Dominguez-Villar M, Mariappan M, Ekong UD. J Immunol. 2023 Mar 15. PMID: 36722941.
Experimental VX2 Rabbit Liver Tumor Model in Carbon Tetrachloride-Induced Cirrhosis of the Liver.Santana JG, Shewarega A, Nam D, Kahl V, Madoff DC, Zhang X, Chapiro J. J Vasc Interv Radiol. 2023 Mar; 2022 Dec 5. PMID: 36473611.
Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.Gaspar RC, Lyu K, Hubbard BT, Leitner BP, Luukkonen PK, Hirabara SM, Sakuma I, Nasiri A, Zhang D, Kahn M, Cline GW, Pauli JR, Perry RJ, Petersen KF, Shulman GI. Diabetologia. 2023 Mar; 2022 Dec 1. PMID: 36456864.
MR Imaging-Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver.Santana JG, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald LA, Boustani A, Walsh JJ, Kucukkaya AS, Malpani R, Madoff DC, Goldberg SN, Ahmed M, Joshi N, Coman D, Chapiro J. J Vasc Interv Radiol. 2023 Mar; 2022 Nov 21. PMID: 36423815.
Single-cell transcriptomic atlas of Alzheimer's disease middle temporal gyrus reveals region, cell type and sex specificity of gene expression with novel genetic risk for MERTK in female.Zhang L, He CH, Coffey S, Yin D, Hsu IU, Su C, Ye Y, Zhang C, Spurrier J, Nicholson L, Rothlin CV, Ghosh S, Gopal PP, Hafler DA, Zhao H, Strittmatter SM. medRxiv. 2023 Feb 23; 2023 Feb 23. PMID: 36865305.
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells.Sacirbegovic F, Günther M, Greco A, Zhao D, Wang X, Zhou M, Rosenberger S, Oberbarnscheidt MH, Held W, McNiff J, Jain D, Höfer T, Shlomchik WD. Immunity. 2023 Feb 14; 2023 Jan 30. PMID: 36720219.
Unique DUOX2(+)ACE2(+) small cholangiocytes are pathogenic targets for primary biliary cholangitis.Li X, Li Y, Xiao J, Wang H, Guo Y, Mao X, Shi P, Hou Y, Zhang X, Zhao N, Zheng M, He Y, Ding J, Tan Y, Liao M, Li L, Peng Y, Li X, Pan Q, Xie Q, Li Q, Li J, Li Y, Chen Z, Huang Y, Assis DN, Cai SY, Boyer JL, Huang X, Tang CE, Liu X, Peng S, Chai J. Nat Commun. 2023 Feb 9; 2023 Feb 9. PMID: 36759512.
Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis.Luukkonen PK, Sakuma I, Gaspar RC, Mooring M, Nasiri A, Kahn M, Zhang XM, Zhang D, Sammalkorpi H, Penttilä AK, Orho-Melander M, Arola J, Juuti A, Zhang X, Yimlamai D, Yki-Järvinen H, Petersen KF, Shulman GI. Proc Natl Acad Sci U S A. 2023 Jan 24; 2023 Jan 20. PMID: 36669104.
Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progression.Fernández-Tussy P, Sun J, Cardelo MP, Price NL, Goedeke L, Xirouchaki CE, Yang X, Pastor-Rojo O, Bennett AM, Tiganis T, Suárez Y, Fernández-Hernando C. bioRxiv. 2023 Jan 20; 2023 Jan 20. PMID: 36711578.
Bile Acid Induced Inflammation and the Role of β-Catenin.Boyer JL. Cell Mol Gastroenterol Hepatol. 2023; 2023 Sep 7. PMID: 37690462.
Clinicopathological significance of neutrophil-rich colorectal carcinoma.Rottmann BG, Patel N, Ahmed M, Deng Y, Ciarleglio M, Vyas M, Jain D, Zhang X. J Clin Pathol. 2023 Jan; 2021 Jul 26. PMID: 34312298.
Locoregional Therapy in the Management of Intrahepatic Cholangiocarcinoma: Is There Sufficient Evidence to Guide Current Clinical Practice?Wang Y, Strazzabosco M, Madoff DC. Curr Oncol Rep. 2022 Dec; 2022 Oct 18. PMID: 36255606.
Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab-based model.Rabiee A, Deng Y, Ciarleglio M, Chan JL, Pons M, Genesca J, Garcia-Tsao G. Hepatol Commun. 2022 Dec; 2022 Oct 10. PMID: 36214066.
Holistic management of hepatocellular carcinoma: The hepatologist's comprehensive playbook.Jaffe A, Taddei TH, Giannini EG, Ilagan-Ying YC, Colombo M, Strazzabosco M. Liver Int. 2022 Dec; 2022 Oct 11. PMID: 36161463.
Association of serum metabolites and gut microbiota at hospital admission with nosocomial infection development in patients with cirrhosis.Bajaj JS, Reddy KR, Tandon P, Garcia-Tsao G, Kamath PS, O'Leary JG, Wong F, Lai J, Vargas H, Thuluvath PJ, Subramanian RM, Pena-Rodriguez M, Sikaroodi M, Thacker LR, Gillevet PM. Liver Transpl. 2022 Dec; 2022 Aug 26. PMID: 36017804.
Fenofibrate Downregulates NF-κB Signaling to Inhibit Pro-inflammatory Cytokine Secretion in Human THP-1 Macrophages and During Primary Biliary Cholangitis.Gallucci GM, Alsuwayt B, Auclair AM, Boyer JL, Assis DN, Ghonem NS. Inflammation. 2022 Dec; 2022 Jul 15. PMID: 35838934.
Diabetes medications and risk of HCC.Plaz Torres MC, Jaffe A, Perry R, Marabotto E, Strazzabosco M, Giannini EG. Hepatology. 2022 Dec; 2022 Mar 22. PMID: 35239194.
Tick transmission of Borrelia burgdorferi to the murine host is not influenced by environmentally acquired midgut microbiota.Narasimhan S, Rajeevan N, Graham M, Wu MJ, DePonte K, Marion S, Masson O, O'Neal AJ, Pedra JHF, Sonenshine DE, Fikrig E. Microbiome. 2022 Oct 17; 2022 Oct 17. PMID: 36253842.
An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma.Madoff DC, Abi-Jaoudeh N, Braxton D, Goyal L, Jain D, Odisio BC, Salem R, Schattner M, Sheth R, Li D. Oncologist. 2022 Oct 1. PMID: 35925597.
Molecular determinants of peri-apical targeting of inositol 1,4,5-trisphosphate receptor type 3 in cholangiocytes.Rodrigues MA, Gomes DA, Fiorotto R, Guerra MT, Weerachayaphorn J, Bo T, Sessa WC, Strazzabosco M, Nathanson MH. Hepatol Commun. 2022 Oct; 2022 Jul 19. PMID: 35852334.
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation.Arumugam S, Qin Y, Liang Z, Han SN, Boodapati SLT, Li J, Lu Q, Flavell RA, Mehal WZ, Ouyang X. Cell Death Differ. 2022 Oct; 2022 Apr 27. PMID: 35477991.
Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity.Wang Q, Zhang B, Stutz B, Liu ZW, Horvath TL, Yang X. Sci Adv. 2022 Sep 2; 2022 Aug 31. PMID: 36044565.
Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.Ventura-Cots M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez-Pinto H, Costa A, Degré D, Fernandez-Carrillo C, Ganne-Carrie N, Garcia-Tsao G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez-Sanchez N, Miquel R, Moreno C, Mounajjed T, Odena G, Kim W, Sancho-Bru P, Warren Sands R, Szafranska J, Verset L, Schnabl B, Sempoux C, Shah V, Shawcross DL, Stauber RE, Straub BK, Verna E, Tiniakos D, Trépo E, Vargas V, Villanueva C, Woosley JT, Ziol M, Mueller S, Stärkel P, Bataller R. Gut. 2022 Sep; 2022 Jan 6. PMID: 34992134.
Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition.Xu L, Guo J, Moledina DG, Cantley LG. Nat Commun. 2022 Aug 19; 2022 Aug 19. PMID: 35986026.
Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy.Boddupalli CS, Nair S, Belinsky G, Gans J, Teeple E, Nguyen TH, Mehta S, Guo L, Kramer ML, Ruan J, Wang H, Davison M, Kumar D, Vidyadhara DJ, Zhang B, Klinger K, Mistry PK. Elife. 2022 Aug 16; 2022 Aug 16. PMID: 35972072.
Tissue-specific modifier alleles determine Mertk loss-of-function traits.Akalu YT, Mercau ME, Ansems M, Hughes LD, Nevin J, Alberto EJ, Liu XN, He LZ, Alvarado D, Keler T, Kong Y, Philbrick WM, Bosenberg M, Finnemann SC, Iavarone A, Lasorella A, Rothlin CV, Ghosh S. Elife. 2022 Aug 15; 2022 Aug 15. PMID: 35969037.
Early mechanical ventilation for grade IV hepatic encephalopathy is associated with increased mortality among patients with cirrhosis: an exploratory study.Saffo S, Garcia-Tsao G. Acute Crit Care. 2022 Aug; 2022 Aug 18. PMID: 35977889.
Interspecies commensal interactions have nonlinear impacts on host immunity.Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Cell Host Microbe. 2022 Jul 13; 2022 May 30. PMID: 35640610.
Regulation of the urea cycle by CPS1 O-GlcNAcylation in response to dietary restriction and aging.Wu J, Liu J, Lapenta K, Desrouleaux R, Li MD, Yang X. J Mol Cell Biol. 2022 Jul 5. PMID: 35285892.
Portal pressure reductions induced by nonselective beta-blockers improve outcomes and decrease mortality in patients with cirrhosis with and without ascites.Turco L, García-Tsao G. Clin Liver Dis (Hoboken). 2022 Jul; 2022 Jun 3. PMID: 35899241.
Within-host evolution of a gut pathobiont facilitates liver translocation.Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Kriegel MA, Palm NW. Nature. 2022 Jul; 2022 Jul 13. PMID: 35831502.
MR Imaging Biomarkers for the Prediction of Outcome after Radiofrequency Ablation of Hepatocellular Carcinoma: Qualitative and Quantitative Assessments of the Liver Imaging Reporting and Data System and Radiomic Features.Petukhova-Greenstein A, Zeevi T, Yang J, Chai N, DiDomenico P, Deng Y, Ciarleglio M, Haider SP, Onyiuke I, Malpani R, Lin M, Kucukkaya AS, Gottwald LA, Gebauer B, Revzin M, Onofrey J, Staib L, Gunabushanam G, Taddei T, Chapiro J. J Vasc Interv Radiol. 2022 Jul; 2022 Apr 20. PMID: 35460887.