Recent Publications

• Disruptions in Reward-Guided Decision-Making Functions Are Predictive of Greater Oral Oxycodone Self-Administration in Male and Female Rats.LaRocco K, Villiamma P, Hill J, Russell MA, DiLeone RJ, Groman SM. Biol Psychiatry Glob Open Sci. 2025 May; 2025 Jan 21. PMID: 40083740.
• Vitamin D's Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [(11)C]-PHNO Positron Emission Tomography Study.Worhunsky PD, Mignosa MM, Gallezot JD, Pittman B, Nabulsi NB, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone RJ, Carson RE, Malison RT, Potenza MN, Angarita GA. Biol Psychiatry. 2025 Mar 15; 2024 Oct 10. PMID: 39395473.
• Xylazine induces dopamine release and augments the effects of fentanyl.Trinko JR, Foscue E, Kong EM, Basu A, Corstens AM, Thompson SL, Kaye AP, Taylor JR, DiLeone RJ. J Clin Invest. 2024 Nov 15; 2024 Nov 15. PMID: 39545408.
• Sex differences in oxycodone-taking behaviors are linked to disruptions in reward-guided, decision-making functions.LaRocco K, Villiamma P, Hill J, Russell MA, DiLeone RJ, Groman SM. bioRxiv. 2024 Apr 11; 2024 Apr 11. PMID: 38645212.
• The endogenous opioid system in the medial prefrontal cortex mediates ketamine's antidepressant-like actions.Jiang C, DiLeone RJ, Pittenger C, Duman RS. Transl Psychiatry. 2024 Feb 12; 2024 Feb 12. PMID: 38346984.
• The endogenous opioid system in the medial prefrontal cortex mediates ketamine's antidepressant-like actions.Pittenger C, Jiang C, DiLeone R, Duman R. Res Sq. 2023 Oct 3; 2023 Oct 3. PMID: 37886526.
• Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study.van Galen KA, Schrantee A, Ter Horst KW, la Fleur SE, Booij J, Constable RT, Schwartz GJ, DiLeone RJ, Serlie MJ. Nat Metab. 2023 Jun; 2023 Jun 12. PMID: 37308722.
• Ketogenic diet enhances the effects of oxycodone in mice.Trinko R, Diaz DM, Foscue E, Thompson SL, Taylor JR, DiLeone RJ. Sci Rep. 2023 May 9; 2023 May 9. PMID: 37160959.
• Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [(18)F]FPEB and positron emission tomography study in rats.Asch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I. Neuropsychopharmacology. 2023 Feb; 2022 Sep 13. PMID: 36100654.
• Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear.Lee B, Pothula S, Wu M, Kang H, Girgenti MJ, Picciotto MR, DiLeone RJ, Taylor JR, Duman RS. Mol Psychiatry. 2022 May; 2022 Apr 14. PMID: 35418600.
• Orexin 1 Receptor Antagonism in the Basolateral Amygdala Shifts the Balance From Pro- to Antistress Signaling and Behavior.Yaeger JDW, Krupp KT, Jacobs BM, Onserio BO, Meyerink BL, Cain JT, Ronan PJ, Renner KJ, DiLeone RJ, Summers CH. Biol Psychiatry. 2022 May 1; 2022 Jan 19. PMID: 35279280.
• Cerebellar neurons that curb food consumption.Simerly R, DiLeone R. Nature. 2021 Dec. PMID: 34789886.
• The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity.van Galen KA, Booij J, Schrantee A, Adriaanse SM, Unmehopa UA, Fliers E, Schwartz GJ, DiLeone RJ, Ter Horst KW, la Fleur SE, Serlie MJ. Metabolism. 2021 Oct; 2021 Jul 29. PMID: 34331964.
• Bringing in the ACE(i): Angiotensin-Converting Enzyme Inhibitors as Antidepressants.Hare BD, DiLeone RJ. Biol Psychiatry. 2020 Sep 1. PMID: 32792051.
• Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption.Bond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. J Neurosci. 2020 Jun 10; 2020 Apr 30. PMID: 32354856.
• Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice.Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Durand-de Cuttoli R, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ. Nat Neurosci. 2020 May; 2020 Apr 13. PMID: 32284606.
• Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)-hydroxynorketamine metabolite.Hare BD, Pothula S, DiLeone RJ, Duman RS. Neuropharmacology. 2020 Apr; 2020 Jan 9. PMID: 31926944.
• Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes.Groman SM, Keistler C, Keip AJ, Hammarlund E, DiLeone RJ, Pittenger C, Lee D, Taylor JR. Neuron. 2019 Aug 21; 2019 Jun 25. PMID: 31253468.
• Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects.Hare BD, Shinohara R, Liu RJ, Pothula S, DiLeone RJ, Duman RS. Nat Commun. 2019 Jan 15; 2019 Jan 15. PMID: 30644390.
• Striatal dopamine regulates systemic glucose metabolism in humans and mice.Ter Horst KW, Lammers NM, Trinko R, Opland DM, Figee M, Ackermans MT, Booij J, van den Munckhof P, Schuurman PR, Fliers E, Denys D, DiLeone RJ, la Fleur SE, Serlie MJ. Sci Transl Med. 2018 May 23. PMID: 29794060.
• Down-regulation of miRNAs in the brain and development of diet-induced obesity.Maldonado-Avilés JG, Guarnieri DJ, Zhu X, DiLeone RJ. Int J Dev Neurosci. 2018 Feb; 2017 Jun 23. PMID: 28652200.
• Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala.Keistler CR, Hammarlund E, Barker JM, Bond CW, DiLeone RJ, Pittenger C, Taylor JR. J Neurosci. 2017 Apr 26; 2017 Mar 23. PMID: 28336571.
• Lip Sync: Gamma Rhythms Orchestrate Top-Down Control of Feeding Circuits.Narayanan NS, DiLeone RJ. Cell Metab. 2017 Mar 7. PMID: 28273473.
• Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression.Banasr M, Lepack A, Fee C, Duric V, Maldonado-Aviles J, DiLeone R, Sibille E, Duman RS, Sanacora G. Chronic Stress (Thousand Oaks). 2017 Feb; 2017 Aug 3. PMID: 28835932.
• The vitamin D metabolites 25(OH)D and 1,25(OH)(2)D are not related to either glucose metabolism or insulin action in obese women.Ter Horst KW, Versteeg RI, Gilijamse PW, Ackermans MT, Heijboer AC, Romijn JA, la Fleur SE, Trinko R, DiLeone RJ, Serlie MJ. Diabetes Metab. 2016 Dec; 2016 Jun 1. PMID: 27262368.
• Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research.Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AFT, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK. Biol Psychiatry. 2016 Jul 15. PMID: 27346079.
• Innate Fear-Induced Weight Regulation in the C57BL/6J Mouse.Genné-Bacon EA, Trinko JR, DiLeone RJ. Front Behav Neurosci. 2016; 2016 Jul 4. PMID: 27458352.
• Vitamin D3: A Role in Dopamine Circuit Regulation, Diet-Induced Obesity, and Drug Consumption.Trinko JR, Land BB, Solecki WB, Wickham RJ, Tellez LA, Maldonado-Aviles J, de Araujo IE, Addy NA, DiLeone RJ. eNeuro. 2016 Mar-Apr; 2016 May 19. PMID: 27257625.
• Activity of D1/2 Receptor Expressing Neurons in the Nucleus Accumbens Regulates Running, Locomotion, and Food Intake.Zhu X, Ottenheimer D, DiLeone RJ. Front Behav Neurosci. 2016; 2016 Apr 12. PMID: 27147989.
• Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation.Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ. Cell Metab. 2016 Apr 12. PMID: 27076082.
• Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit.D'Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK. Elife. 2016 Mar 14; 2016 Mar 14. PMID: 26974347.
• Serotonin (5-HT) 5-HT2A Receptor (5-HT2AR):5-HT2CR Imbalance in Medial Prefrontal Cortex Associates with Motor Impulsivity.Anastasio NC, Stutz SJ, Fink LH, Swinford-Jackson SE, Sears RM, DiLeone RJ, Rice KC, Moeller FG, Cunningham KA. ACS Chem Neurosci. 2015 Jul 15; 2015 Jul 7. PMID: 26120876.
• Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions.Fuchikami M, Thomas A, Liu R, Wohleb ES, Land BB, DiLeone RJ, Aghajanian GK, Duman RS. Proc Natl Acad Sci U S A. 2015 Jun 30; 2015 Jun 8. PMID: 26056286.
• Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior.Dwyer JM, Maldonado-Avilés JG, Lepack AE, DiLeone RJ, Duman RS. Proc Natl Acad Sci U S A. 2015 May 12; 2015 Apr 27. PMID: 25918363.
• Neuropeptide Y activity in the nucleus accumbens modulates feeding behavior and neuronal activity.van den Heuvel JK, Furman K, Gumbs MC, Eggels L, Opland DM, Land BB, Kolk SM, Narayanan NS, Fliers E, Kalsbeek A, DiLeone RJ, la Fleur SE. Biol Psychiatry. 2015 Apr 1; 2014 Jun 18. PMID: 25109664.
• Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome.Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561540.
• Leptin mediates the increase in blood pressure associated with obesity.Simonds SE, Pryor JT, Ravussin E, Greenway FL, Dileone R, Allen AM, Bassi J, Elmquist JK, Keogh JM, Henning E, Myers MG Jr, Licinio J, Brown RD, Enriori PJ, O'Rahilly S, Sternson SM, Grove KL, Spanswick DC, Farooqi IS, Cowley MA. Cell. 2014 Dec 4. PMID: 25480301.
• Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding.Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Mol Psychiatry. 2014 Oct; 2014 Apr 15. PMID: 24732670.
• GABAergic and glutamatergic efferents of the mouse ventral tegmental area.Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L, Picciotto MR. J Comp Neurol. 2014 Oct 1. PMID: 24715505.
• Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S. Proc Natl Acad Sci U S A. 2014 Aug 12; 2014 Jul 28. PMID: 25071172.
• Heightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals--results of a pilot study.Udo T, Weinberger AH, Grilo CM, Brownell KD, DiLeone RJ, Lampert R, Matlin SL, Yanagisawa K, McKee SA. Obes Res Clin Pract. 2014 May-Jun. PMID: 24847667.
• REDD1 is essential for stress-induced synaptic loss and depressive behavior.Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. Nat Med. 2014 May; 2014 Apr 13. PMID: 24728411.
• Optogenetic inhibition of neurons by internal light production.Land BB, Brayton CE, Furman KE, Lapalombara Z, Dileone RJ. Front Behav Neurosci. 2014; 2014 Apr 1. PMID: 24744708.
• Inhaling: endocannabinoids and food intake.Maldonado-Avilés JG, Dileone RJ. Nat Neurosci. 2014 Mar. PMID: 24569827.
• Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala.Arendt DH, Hassell J, Li H, Achua JK, Guarnieri DJ, Dileone RJ, Ronan PJ, Summers CH. Psychoneuroendocrinology. 2014 Feb; 2013 Oct 30. PMID: 24485472.
• Medial prefrontal D1 dopamine neurons control food intake.Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Nat Neurosci. 2014 Feb; 2014 Jan 19. PMID: 24441680.
• Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence.Anastasio NC, Stutz SJ, Fox RG, Sears RM, Emeson RB, DiLeone RJ, O'Neil RT, Fink LH, Li D, Green TA, Moeller FG, Cunningham KA. Neuropsychopharmacology. 2014 Jan; 2013 Aug 13. PMID: 23939424.
• The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum.Gourley SL, Olevska A, Zimmermann KS, Ressler KJ, Dileone RJ, Taylor JR. Eur J Neurosci. 2013 Aug; 2013 May 8. PMID: 23651226.
• BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia.Sarhan M, Pawlowski SA, Barthas F, Yalcin I, Kaufling J, Dardente H, Zachariou V, Dileone RJ, Barrot M, Veinante P. Int J Neuropsychopharmacol. 2013 Aug; 2013 Feb 21. PMID: 23425507.
• Flavor-independent maintenance, extinction, and reinstatement of fat self-administration in mice.Tellez LA, Ferreira JG, Medina S, Land BB, DiLeone RJ, de Araujo IE. Biol Psychiatry. 2013 May 1. PMID: 23587200.
• Modeling the effects of positive and negative mood on the ability to resist eating in obese and non-obese individuals.Udo T, Grilo CM, Brownell KD, Weinberger AH, Dileone RJ, McKee SA. Eat Behav. 2013 Jan; 2012 Oct 31. PMID: 23265400.
• Transcriptional plasticity in the brain following metabolic challenge.Guarnieri DJ, DiLeone RJ. Neuropsychopharmacology. 2013 Jan. PMID: 23147479.
• Prefrontal D1 dopamine signaling is required for temporal control.Narayanan NS, Land BB, Solder JE, Deisseroth K, DiLeone RJ. Proc Natl Acad Sci U S A. 2012 Dec 11; 2012 Nov 26. PMID: 23185016.
• Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding.Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, Dileone RJ, Koleske AJ, Taylor JR. Proc Natl Acad Sci U S A. 2012 Dec 11; 2012 Nov 26. PMID: 23185000.
• The drive to eat: comparisons and distinctions between mechanisms of food reward and drug addiction.DiLeone RJ, Taylor JR, Picciotto MR. Nat Neurosci. 2012 Oct; 2012 Sep 25. PMID: 23007187.
• Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals.Kanoski SE, Zhao S, Guarnieri DJ, DiLeone RJ, Yan J, De Jonghe BC, Bence KK, Hayes MR, Grill HJ. Am J Physiol Endocrinol Metab. 2012 Aug 15; 2012 Jun 12. PMID: 22693203.
• Losing the lust for life: a new role for an old feeding Peptide?Land BB, DiLeone RJ. Neuron. 2012 Aug 9. PMID: 22884320.
• Serum and plasma brain-derived neurotrophic factor (BDNF) in abstinent alcoholics and social drinkers.D'Sa C, Dileone RJ, Anderson GM, Sinha R. Alcohol. 2012 May; 2012 Feb 22. PMID: 22364688.
• Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction.Guarnieri DJ, Brayton CE, Richards SM, Maldonado-Aviles J, Trinko JR, Nelson J, Taylor JR, Gourley SL, DiLeone RJ. Biol Psychiatry. 2012 Feb 15. PMID: 21855858.
• Increased serum brain-derived neurotrophic factor is predictive of cocaine relapse outcomes: a prospective study.D'Sa C, Fox HC, Hong AK, Dileone RJ, Sinha R. Biol Psychiatry. 2011 Oct 15; 2011 Jul 8. PMID: 21741029.
• Can food be addictive? Public health and policy implications.Gearhardt AN, Grilo CM, DiLeone RJ, Brownell KD, Potenza MN. Addiction. 2011 Jul; 2011 Feb 14. PMID: 21635588.
• Nicotine decreases food intake through activation of POMC neurons.Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR. Science. 2011 Jun 10. PMID: 21659607.
• Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat.Mul JD, la Fleur SE, Toonen PW, Afrasiab-Middelman A, Binnekade R, Schetters D, Verheij MM, Sears RM, Homberg JR, Schoffelmeer AN, Adan RA, DiLeone RJ, De Vries TJ, Cuppen E. PLoS One. 2011 May 5; 2011 May 5. PMID: 21573180.
• Neuroscience gets nutrition.DiLeone RJ. Nat Neurosci. 2011 Mar. PMID: 21346742.
• Erk1/2 mediates leptin receptor signaling in the ventral tegmental area.Trinko R, Gan G, Gao XB, Sears RM, Guarnieri DJ, DiLeone RJ. PLoS One. 2011; 2011 Nov 4. PMID: 22076135.
• The neuronal PAS domain protein 4 (Npas4) is required for new and reactivated fear memories.Ploski JE, Monsey MS, Nguyen T, DiLeone RJ, Schafe GE. PLoS One. 2011; 2011 Aug 22. PMID: 21887312.
• Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior.Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF 3rd, DiLeone RJ, Birnbaum SG, Cooper DC, McClung CA. Biol Psychiatry. 2010 Sep 15; 2010 Jun 29. PMID: 20591414.
• Wnt2 expression and signaling is increased by different classes of antidepressant treatments.Okamoto H, Voleti B, Banasr M, Sarhan M, Duric V, Girgenti MJ, Dileone RJ, Newton SS, Duman RS. Biol Psychiatry. 2010 Sep 15; 2010 Jun 8. PMID: 20570247.
• Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone.Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK, DiLeone RJ. J Neurosci. 2010 Jun 16. PMID: 20554878.
• Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement.Sharf R, Sarhan M, Brayton CE, Guarnieri DJ, Taylor JR, DiLeone RJ. Biol Psychiatry. 2010 Apr 15; 2010 Feb 26. PMID: 20189166.
• Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization.Sharf R, Guarnieri DJ, Taylor JR, DiLeone RJ. Brain Res. 2010 Mar 4; 2009 Dec 23. PMID: 20034477.
• Role of orexin/hypocretin in dependence and addiction.Sharf R, Sarhan M, Dileone RJ. Brain Res. 2010 Feb 16; 2009 Aug 20. PMID: 19699189.
• Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation.Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ. Cell Metab. 2010 Jan. PMID: 20074530.
• Metabolic hormones, dopamine circuits, and feeding.Narayanan NS, Guarnieri DJ, DiLeone RJ. Front Neuroendocrinol. 2010 Jan; 2009 Oct 28. PMID: 19836414.
• Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction.Gourley SL, Howell JL, Rios M, DiLeone RJ, Taylor JR. Learn Mem. 2009 Dec; 2009 Nov 19. PMID: 19926781.
• Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease.Berton O, Guigoni C, Li Q, Bioulac BH, Aubert I, Gross CE, Dileone RJ, Nestler EJ, Bezard E. Biol Psychiatry. 2009 Sep 15; 2009 May 28. PMID: 19481198.
• DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine.Winstanley CA, Green TA, Theobald DE, Renthal W, LaPlant Q, DiLeone RJ, Chakravarty S, Nestler EJ. Pharmacol Biochem Behav. 2009 Sep; 2008 Dec 16. PMID: 19135469.
• Leptin: taking the path less traveled.DiLeone RJ. Cell Metab. 2009 Aug. PMID: 19656482.
• The influence of leptin on the dopamine system and implications for ingestive behavior.DiLeone RJ. Int J Obes (Lond). 2009 Jun. PMID: 19528975.
• Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward.Graham DL, Krishnan V, Larson EB, Graham A, Edwards S, Bachtell RK, Simmons D, Gent LM, Berton O, Bolanos CA, DiLeone RJ, Parada LF, Nestler EJ, Self DW. Biol Psychiatry. 2009 Apr 15; 2008 Nov 6. PMID: 18990365.
• Primate models of schizophrenia: future possibilities.Simen AA, DiLeone R, Arnsten AF. Prog Brain Res. 2009; 2009 Nov 20. PMID: 20302824.
• The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior.Wallace DL, Vialou V, Rios L, Carle-Florence TL, Chakravarty S, Kumar A, Graham DL, Green TA, Kirk A, Iñiguez SD, Perrotti LI, Barrot M, DiLeone RJ, Nestler EJ, Bolaños-Guzmán CA. J Neurosci. 2008 Oct 8. PMID: 18842886.
• Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell.Sharf R, Sarhan M, Dileone RJ. Biol Psychiatry. 2008 Aug 1; 2008 Apr 18. PMID: 18423425.
• MicroRNAs: a new class of gene regulators.Guarnieri DJ, DiLeone RJ. Ann Med. 2008. PMID: 18382885.
• Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability.Benavides DR, Quinn JJ, Zhong P, Hawasli AH, DiLeone RJ, Kansy JW, Olausson P, Yan Z, Taylor JR, Bibb JA. J Neurosci. 2007 Nov 21. PMID: 18032670.
• Dynamic contribution of nestin-expressing stem cells to adult neurogenesis.Lagace DC, Whitman MC, Noonan MA, Ables JL, DeCarolis NA, Arguello AA, Donovan MH, Fischer SJ, Farnbauch LA, Beech RD, DiLeone RJ, Greer CA, Mandyam CD, Eisch AJ. J Neurosci. 2007 Nov 14. PMID: 18003841.
• DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction.Winstanley CA, LaPlant Q, Theobald DE, Green TA, Bachtell RK, Perrotti LI, DiLeone RJ, Russo SJ, Garth WJ, Self DW, Nestler EJ. J Neurosci. 2007 Sep 26. PMID: 17898221.
• Neural mechanisms underlying obesity and drug addiction.Trinko R, Sears RM, Guarnieri DJ, DiLeone RJ. Physiol Behav. 2007 Aug 15; 2007 Jan 16. PMID: 17292426.
• Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse.Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, Self DW. Nat Neurosci. 2007 Aug; 2007 Jul 8. PMID: 17618281.
• Addiction and arousal: alternative roles of hypothalamic peptides.de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M, DiLeone R. J Neurosci. 2006 Oct 11. PMID: 17035520.
• Leptin receptor signaling in midbrain dopamine neurons regulates feeding.Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ. Neuron. 2006 Sep 21. PMID: 16982424.
• Induction of inducible cAMP early repressor expression in nucleus accumbens by stress or amphetamine increases behavioral responses to emotional stimuli.Green TA, Alibhai IN, Hommel JD, DiLeone RJ, Kumar A, Theobald DE, Neve RL, Nestler EJ. J Neurosci. 2006 Aug 9. PMID: 16899718.
• Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress.Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ, Graham D, Tsankova NM, Bolanos CA, Rios M, Monteggia LM, Self DW, Nestler EJ. Science. 2006 Feb 10. PMID: 16469931.
• An essential role for DeltaFosB in the nucleus accumbens in morphine action.Zachariou V, Bolanos CA, Selley DE, Theobald D, Cassidy MP, Kelz MB, Shaw-Lutchman T, Berton O, Sim-Selley LJ, Dileone RJ, Kumar A, Nestler EJ. Nat Neurosci. 2006 Feb; 2006 Jan 15. PMID: 16415864.
• The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance.Georgescu D, Sears RM, Hommel JD, Barrot M, Bolaños CA, Marsh DJ, Bednarek MA, Bibb JA, Maratos-Flier E, Nestler EJ, DiLeone RJ. J Neurosci. 2005 Mar 16. PMID: 15772353.
• Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice.Holder JL Jr, Zhang L, Kublaoui BM, DiLeone RJ, Oz OK, Bair CH, Lee YH, Zinn AR. Am J Physiol Endocrinol Metab. 2004 Jul; 2004 Feb 24. PMID: 14982752.
• Local gene knockdown in the brain using viral-mediated RNA interference.Hommel JD, Sears RM, Georgescu D, Simmons DL, DiLeone RJ. Nat Med. 2003 Dec; 2003 Nov 23. PMID: 14634645.
• Essential role for RGS9 in opiate action.Zachariou V, Georgescu D, Sanchez N, Rahman Z, DiLeone R, Berton O, Neve RL, Sim-Selley LJ, Selley DE, Gold SJ, Nestler EJ. Proc Natl Acad Sci U S A. 2003 Nov 11; 2003 Oct 31. PMID: 14595021.
• Lateral hypothalamic neuropeptides in reward and drug addiction.DiLeone RJ, Georgescu D, Nestler EJ. Life Sci. 2003 Jun 27. PMID: 12801597.
• RGS9 modulates dopamine signaling in the basal ganglia.Rahman Z, Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Chen CK, DiLeone RJ, Schwarz SC, Selley DE, Sim-Selley LJ, Barrot M, Luedtke RR, Self D, Neve RL, Lester HA, Simon MI, Nestler EJ. Neuron. 2003 Jun 19. PMID: 12818179.