NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation
Dodt S, Widdershooven N, Dreisow M, Weiher L, Steuernagel L, Wunderlich F, Brüning J, Fenselau H. NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation. Nature Communications 2024, 15: 5439. PMID: 38937485, PMCID: PMC11211344, DOI: 10.1038/s41467-024-49766-0.Peer-Reviewed Original ResearchConceptsBed nucleus of the stria terminalisNPY-deficient miceBed nucleus of the stria terminalis neuronsGABAergic inputsControl of feeding behaviorPromote feedingAgRP neuronsOrexigenic neuropeptide Y (NPYSuppress food intakeNeuropeptide Y (NPYAmygdala circuitsAnxiety signalsExtended amygdalaCentral amygdalaBed nucleusCeA projectionsStria terminalisSynaptic adaptationDecreased anxietyAmygdalaSynaptic plasticityRelevant circuitsDecreased feedingAnxietyHypothalamic neurons
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