Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism
De Solis A, Del RÃo-MartÃn A, Radermacher J, Chen W, Steuernagel L, Bauder C, Eggersmann F, Morgan D, Cremer A, Sué M, Germer M, Kukat C, Vollmar S, Backes H, Rahmouni K, Kloppenburg P, Brüning J. Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nature Metabolism 2024, 6: 473-493. PMID: 38378998, PMCID: PMC10963273, DOI: 10.1038/s42255-024-00987-z.Peer-Reviewed Original ResearchInhibition of POMC neuronsPOMC neuronsFood intakeAgRP neuronsEffects of Agrp neuron activationActivation of AgRP neuronsActivating AgRP neuronsActivation of AgRPInhibit POMC neuronsProopiomelanocortin (POMC)-expressing neuronsAgRP neuron activityNucleus tractus solitariiRegulate food intakePromote food consumptionSystemic insulin sensitivityControl of feedingParaventricular nucleusTractus solitariiNeuronal inhibitionTH+ neuronsFemale miceChemogenetic receptorsNeuronal activityAgRPInsulin sensitivity
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply