Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor
Engström Ruud L, Font-Gironès F, Zajdel J, Kern L, Teixidor-Deulofeu J, Mannerås-Holm L, Carreras A, Becattini B, Björefeldt A, Hanse E, Fenselau H, Solinas G, Brüning J, Wunderlich T, Bäckhed F, Ruud J. Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor. Cell Reports 2024, 43: 113960. PMID: 38507407, DOI: 10.1016/j.celrep.2024.113960.Peer-Reviewed Original ResearchGlucose to lipid oxidationMetabolomics analysis of bloodImpaired insulin sensitivityRelease of stress hormonesAdipose tissue differentiationAnalysis of bloodGlucose uptakeVisceral fatChronic activationAcute activationGlucose toleranceMetabolomic analysisTranscriptome of muscleObesity treatmentTorpor-like stateNeuronal activityCell-specific activityInsulin sensitivityNauseaMetformin effectsHypothermiaWeight lossNeuronsEnergy homeostasisAugmented glucose uptake
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