2020
Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration
Lee J, Zhang R, Yan M, Duggineni S, Wakeman D, Niles W, Feng Y, Chen J, Hamblin M, Han E, Gonzalez R, Fang X, Zhu Y, Wang J, Xu Y, Wenger D, Seyfried T, An J, Sidman R, Huang Z, Snyder E. Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 31177-31188. PMID: 33219123, PMCID: PMC7733796, DOI: 10.1073/pnas.1911444117.Peer-Reviewed Original ResearchConceptsNeural stem cellsCXCR4 agonistPrototypical neurodegenerative diseaseDonor-derived cellsStem cellsCerebral cortexCNS injuryInflammatory chemokinesHost inflammationUndesirable inflammationCXCL-12Mouse modelTherapeutic impactChemokine CXCL12Stem cell propertiesCell engagementNeurodegenerative diseasesStem cell migrationNSC migrationAgonistsSynthetic functionInflammationChemokinesFundamental stem cell propertiesCXCL12
2014
Neonatal immune-tolerance in mice does not prevent xenograft rejection
Mattis V, Wakeman D, Tom C, Dodiya H, Yeung S, Tran A, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson L, Kordower J, Svendsen C. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Experimental Neurology 2014, 254: 90-98. PMID: 24440640, PMCID: PMC3954854, DOI: 10.1016/j.expneurol.2014.01.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAnimals, Outbred StrainsCells, CulturedCorpus StriatumDisease Models, AnimalFemaleGraft RejectionGraft SurvivalHeterograftsHumansHuntingtin ProteinHuntington DiseaseImmune ToleranceMaleMiceMice, Inbred NODMice, SCIDMice, TransgenicNerve Tissue ProteinsNeural Stem CellsNuclear ProteinsTransplantation, HeterologousConceptsNeonatal toleranceRapid rejectionHuman stem cell transplantationImmune-intact miceSignificant immune rejectionStem cell transplantationHumanized mouse modelXenograft rejectionCell transplantationRodent modelsMouse modelImmune rejectionMiceConflicting resultsStem cell typesXenograftsRecent reportsCell typesRejectionTransplantationRatsDisease
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