2010
14-3-3 Regulates the Lnk/JAK2 Pathway In Hematopoietic Stem and Progenitor Cells
Balcerek J, Jiang J, Bersenev A, Song Y, Wu C, Tong W. 14-3-3 Regulates the Lnk/JAK2 Pathway In Hematopoietic Stem and Progenitor Cells. Blood 2010, 116: 86. DOI: 10.1182/blood.v116.21.86.86.Peer-Reviewed Original ResearchOncogenic JAK2HSPC expansionHematopoietic stemRegulation of JAK2Serine phosphorylation eventsTyrosine kinase JAK2Progenitor cell homeostasisLymphocyte adaptor proteinHSPC developmentPhosphorylation eventsAdaptor proteinScaffold proteinCellular processesSerine residuesKinase JAK2Lnk-/- miceGene productsCritical binding siteRegulatory mechanismsCell homeostasisHSPC homeostasisJAK2 activityInactive stateFunction mutationsJAK2 pathway
2009
Lnk Constrains Oncogenic JAK2-Induced Myeloproliferative Disease in Mice.
Bersenev A, Wu C, Balcerek J, Tong W. Lnk Constrains Oncogenic JAK2-Induced Myeloproliferative Disease in Mice. Blood 2009, 114: 1437. DOI: 10.1182/blood.v114.22.1437.1437.Peer-Reviewed Original ResearchOncogenic JAK2TPO stimulationHematopoietic stem cell homeostasisDownstream signal transduction pathwaysStem cell homeostasisAdaptor protein LNKSignal transduction pathwaysPhysiological negative regulatorCell surface receptorsImportant signaling axisWild-type bone marrow cellsDouble mutantTransduction pathwaysJAK2 activationHSC poolLNK deficiencyNegative regulatorJanus kinaseCell homeostasisCell developmentCytokine receptorsSignaling AxisJAK2 pathwayChromosomal translocationsMPD development
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply