High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior
Cabrera-Mendoza B, MartÃnez-Magaña JJ, Genis-Mendoza AD, Sarmiento E, RuÃz-Ramos D, Tovilla-Zárate CA, González-Castro TB, Juárez-Rojop IE, GarcÃa-de la Cruz DD, López-Armenta M, Real F, GarcÃa-Dolores F, Flores G, Vázquez-Roque RA, Lanzagorta N, Escamilla M, Saucedo-Uribe E, RodrÃguez-Mayoral O, Jiménez-Genchi J, Castañeda-González C, Roche-Bergua A, Nicolini H. High polygenic burden is associated with blood DNA methylation changes in individuals with suicidal behavior. Journal Of Psychiatric Research 2020, 123: 62-71. PMID: 32036075, DOI: 10.1016/j.jpsychires.2020.01.008.Peer-Reviewed Original ResearchConceptsDNA methylation differencesMethylation differencesDiscovery samplePolygenic risk scoresDNA methylation changesSuicidal behaviorGenetic burdenPolygenic burdenPsychiatric Genomics ConsortiumEpigenetic variationATP bindingDNA methylationEnvironmental factorsMethylation changesEpigenetic changesGenomics ConsortiumPolygenic componentGenesGenetic variantsPRS analysesRisk scoreMexican individualsBurdenIntegration of approachesNeurodevelopmentEpigenome-Wide Analysis Reveals DNA Methylation Alteration in ZFP57 and Its Target RASGFR2 in a Mexican Population Cohort with Autism
Aspra Q, Cabrera-Mendoza B, Morales-MarÃn ME, Márquez C, Chicalote C, Ballesteros A, Aguilar M, Castro X, Gómez-Cotero A, Balboa-Verduzco AM, Albores-Gallo L, Nafate-López O, MarcÃn-Salazar CA, Sánchez P, Lanzagorta-Piñol N, López-Armenta FO, Nicolini H. Epigenome-Wide Analysis Reveals DNA Methylation Alteration in ZFP57 and Its Target RASGFR2 in a Mexican Population Cohort with Autism. Children 2022, 9: 462. PMID: 35455506, PMCID: PMC9025761, DOI: 10.3390/children9040462.Peer-Reviewed Original ResearchDNA methylationGenome-wide differencesIllumina 450k arrayDNA methylation patternsDNA methylation profilesDNA methylation studiesDNA methylation alterationsWide analysisMethylation patternsEnvironmental factorsMethylation alterationsMethylation profilesMethylation studiesDifferent tissuesMethylationASD etiologyASD pathophysiologyComplex neurodevelopmental disorderMolecular alterationsEpithelium cellsNeurodevelopmental disordersComplex interactionsZFP57RasGRF2Diversity
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