2025
Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy
Guo M, Wu Y, Hobson C, Su Y, Qian S, Krueger E, Christensen R, Kroeschell G, Bui J, Chaw M, Zhang L, Liu J, Hou X, Han X, Lu Z, Ma X, Zhovmer A, Combs C, Moyle M, Yemini E, Liu H, Liu Z, Benedetto A, La Riviere P, Colón-Ramos D, Shroff H. Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy. Nature Communications 2025, 16: 313. PMID: 39747824, PMCID: PMC11697233, DOI: 10.1038/s41467-024-55267-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansDeep LearningImage Processing, Computer-AssistedMiceMicroscopy, ConfocalMicroscopy, FluorescenceNeural Networks, ComputerConceptsAdaptive optics techniquesMulti-photonDeep learning-based strategyAberration compensationLearning-based strategyTrained neural networkImprove image qualityOptical aberrationsNeural networkImage quantitationOptical techniquesDiverse datasetsSuper-resolution microscopyLight sheetRestore dataImage qualityImage signalNetworkImage inspectionImage acquisitionImage stacksOpticsResolutionImagesFluorescence microscopy
2022
Incorporating the image formation process into deep learning improves network performance
Li Y, Su Y, Guo M, Han X, Liu J, Vishwasrao H, Li X, Christensen R, Sengupta T, Moyle M, Rey-Suarez I, Chen J, Upadhyaya A, Usdin T, Colón-Ramos D, Liu H, Wu Y, Shroff H. Incorporating the image formation process into deep learning improves network performance. Nature Methods 2022, 19: 1427-1437. PMID: 36316563, PMCID: PMC9636023, DOI: 10.1038/s41592-022-01652-7.Peer-Reviewed Original Research
2013
Serotonergic Neurosecretory Synapse Targeting Is Controlled by Netrin-Releasing Guidepost Neurons in Caenorhabditis elegans
Nelson JC, Colón-Ramos DA. Serotonergic Neurosecretory Synapse Targeting Is Controlled by Netrin-Releasing Guidepost Neurons in Caenorhabditis elegans. Journal Of Neuroscience 2013, 33: 1366-1376. PMID: 23345213, PMCID: PMC3584569, DOI: 10.1523/jneurosci.3471-12.2012.Peer-Reviewed Original ResearchConceptsUNC-34/EnabledReceptor UNC-40/DCCUNC-6/NetrinUNC-40/DCCNetrin receptor UNC-40/DCCCaenorhabditis elegansUNC-40NSM neuronsSynapse targetingMolecular linkMolecular mechanismsNovel mechanismSpatial specificitySite targetsRelease sitesNetrinPostsynaptic partnersSite formationRing neuronsSpecific regionsTargetingCaenorhabditisElegansLamellipodinGuidepost neurons
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