2024
Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease
Pahl J, Prokopiou P, Bueichekú E, Schultz A, Papp K, Farrell M, Rentz D, Sperling R, Johnson K, Jacobs H. Locus coeruleus integrity and left frontoparietal connectivity provide resilience against attentional decline in preclinical alzheimer’s disease. Alzheimer's Research & Therapy 2024, 16: 119. PMID: 38822365, PMCID: PMC11140954, DOI: 10.1186/s13195-024-01485-w.Peer-Reviewed Original ResearchConceptsDigit Symbol Substitution TestLC integrityLocus coeruleusAttentional declineCognitive declineDigit-symbol substitution test performanceHarvard Aging Brain StudyResting-state functional MRILocus coeruleus integrityNetwork functional connectivityAlzheimer's diseaseAging Brain StudyPreclinical Alzheimer's diseaseCognitive follow-upYears of educationNeural reserveNeural correlatesAttentional performanceAttention deficitMixed effects analysisCortical target regionsSubstitution TestCognitive changesFrontoparietal connectivityFunctional MRISpatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Bueichekú E, Diez I, Kim C, Becker J, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition. Nature Aging 2024, 4: 625-637. PMID: 38664576, PMCID: PMC11108787, DOI: 10.1038/s43587-024-00626-y.Peer-Reviewed Original ResearchConceptsTau spreadingDisease pathologyGene expression profilesTau positron emission tomography imagingTranscriptomic informationLocus coeruleusHyperphosphorylated tauAlzheimer's disease pathologyTau accumulationBiological functionsExpression profilesTau depositionGenetic featuresCortical tauAlzheimer's diseaseLocus coeruleus integrityTauAssociated with lower cognitive performanceLower cognitive performanceTransport regulationLC integrityCognitive performanceAlzheimerAllocortical regionsSpatiotemporal patterns
2023
Spatiotemporal Assessment of Locus Coeruleus Integrity Predicting Cortical Tau and Cognition
Bueichekú E, Diez I, Kim C, Becker A, Koops E, Kwong K, Papp K, Salat D, Bennett D, Rentz D, Sperling R, Johnson K, Sepulcre J, Jacobs H. Spatiotemporal Assessment of Locus Coeruleus Integrity Predicting Cortical Tau and Cognition. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079747.Peer-Reviewed Original ResearchLC integrityLocus coeruleusLower cognitive performanceLongitudinal tau accumulationCognitive performanceEmergence of cognitive declineAssociated with lower cognitive performanceTemporal cortex areasIn vivo neuroimaging dataTau accumulationTau progressionCortical tau depositionAlzheimer's diseaseNeuroimaging studiesMTL structuresNeuroimaging dataAD-related pathologyCognitive declineCortex areaPartial correlationMisfolded tau proteinContext of ADGLM analysisSites of tauLipid biosynthetic processLeft Frontoparietal Connectivity Counteracts Locus Coeruleus‐Related Attentional Decline in Preclinical Alzheimer’s Disease
Pahl J, Prokopiou P, Bueicheku E, Schultz A, Papp K, Rentz D, Sperling R, Johnson K, Jacobs H. Left Frontoparietal Connectivity Counteracts Locus Coeruleus‐Related Attentional Decline in Preclinical Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.079733.Peer-Reviewed Original ResearchDigit Symbol Substitution TestLC integrityLocus coeruleusFunctional connectivityCognitive declineAttentional controlAssociated with less steep declinesAssess attentional controlHarvard Aging Brain StudyPrefrontal functional connectivityAging Brain StudyPreclinical Alzheimer's diseaseCognitive follow-upYears of educationAlzheimer's diseaseNeural reserveFrontoparietal networkBrain mechanismsMixed effects analysisAttention deficitSubstitution TestCognitive performanceDSST performanceAttentional declinePreclinical AD
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