Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals
Engels‐Domínguez N, Riphagen J, Van Egroo M, Koops E, Smegal L, Becker J, Prokopiou P, Bueichekú E, Kwong K, Rentz D, Salat D, Sperling R, Johnson K, Jacobs H. Lower Locus Coeruleus Integrity Signals Elevated Entorhinal Tau and Clinical Progression in Asymptomatic Older Individuals. Annals Of Neurology 2024, 96: 650-661. PMID: 39007398, PMCID: PMC11534559, DOI: 10.1002/ana.27022.Peer-Reviewed Original ResearchConceptsLocus coeruleus integrityClinical Dementia RatingBeta-amyloidHippocampal volumePositron emission tomographyClinical progressionAsymptomatic individualsReceiver operating characteristic analysisCortical tau depositionCox proportional hazards modelsLociAccumulation of pathologyBeta-amyloid burdenAsymptomatic older individualsMild cognitive impairmentTau depositionProportional hazards modelTau signalEC tauLocus coeruleusPET-negativeEntorhinal tauCognitive impairmentScreening instrumentCognitive decline
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