Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
de Bruin EC, McGranahan N, Mitter R, Salm M, Wedge DC, Yates L, Jamal-Hanjani M, Shafi S, Murugaesu N, Rowan AJ, Grönroos E, Muhammad MA, Horswell S, Gerlinger M, Varela I, Jones D, Marshall J, Voet T, Van Loo P, Rassl DM, Rintoul RC, Janes SM, Lee SM, Forster M, Ahmad T, Lawrence D, Falzon M, Capitanio A, Harkins TT, Lee CC, Tom W, Teefe E, Chen SC, Begum S, Rabinowitz A, Phillimore B, Spencer-Dene B, Stamp G, Szallasi Z, Matthews N, Stewart A, Campbell P, Swanton C. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science 2014, 346: 251-256. PMID: 25301630, PMCID: PMC4636050, DOI: 10.1126/science.1253462.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerOperable non-small cell lung cancerHuman non-small cell lung cancerSubclonal diversificationDriver mutationsCell lung cancerLung cancer evolutionFormer smokersDismal prognosisLung cancerTreatment successTumor latencyCarcinogen exposureCytidine deaminase activityCopy number alterationsClinical detectionSmokersIntratumor heterogeneityTumorsNumber alterationsRelative decreaseDeaminase activityMutationsTemporal dissectionPrognosis
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