2025
L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats
Nunes E, Kimble V, Rajadhyaksha A, Addy N. L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats. Neuroscience 2025, 568: 314-322. PMID: 39761823, DOI: 10.1016/j.neuroscience.2025.01.003.Peer-Reviewed Original ResearchThis study found that isradipine reduces anxiety and depression-like symptoms during cocaine withdrawal in rats, suggesting potential treatment for mood disorders in addiction.
2024
L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure
Nunes E, Kebede N, Rajadhyaksha A, Addy N. L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure. Neuropharmacology 2024, 257: 110031. PMID: 38871116, PMCID: PMC11334593, DOI: 10.1016/j.neuropharm.2024.110031.Peer-Reviewed Original ResearchChronic unpredictable stressHome cage controlsElevated plus mazeForced swim testSucrose preference testCUS-induced decreaseChronic stress exposureImmobility timeStress exposureL-type calcium channelsDays of chronic unpredictable stressAnxiogenic-like behavioral responsesForced swim test immobility timeBehavioral responsesPre-existing mental health challengesAntidepressant-like responseOpen arm timeMood-related disordersRegulation of depressionExposure to chronic stressorsMale ratsL-type calcium channel blocker isradipineArm timePlus mazeSucrose preference
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