The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex
Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro J, Narula S, Brenton J, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas J, de Seze J, Tenembaum S, Stone R, Casez O, Carra-Dallière C, Neuteboom R, Ahsan N, Arroyo H, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich D, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo C, Kantarci O, Shapiro E, Okuda D, Pelletier D. The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex. Journal Of Neurology 2024, 271: 4019-4027. PMID: 38564056, PMCID: PMC11323224, DOI: 10.1007/s00415-024-12289-1.Peer-Reviewed Original ResearchRadiologically isolated syndromeSpinal MRIDiagnostic workup of childrenMultiple sclerosisWorkup of childrenFisher's exact testMultivariate logistic regressionInternational longitudinal studyDiagnostic workupConsensus guidelinesExact testMS riskLogistic regressionConclusionsYoung childrenCSFBackgroundCerebrospinal fluidMRIPre-2017Longitudinal studySyndromeRadiologyChildrenAgeSexRisk
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