2025
A series of hydroxychloroquine-associated cardiotoxicity presenting with heart failure
Nazarenko N, Maliha M, Parker M, Borkowski P, Csecs I, Tauras J, Julia Shin J, Pullman J, Sims D, Rochlani Y. A series of hydroxychloroquine-associated cardiotoxicity presenting with heart failure. Annals Of Medicine And Surgery 2025, 87: 1334-1340. DOI: 10.1097/ms9.0000000000002997.Peer-Reviewed Original ResearchSystemic lupus erythematosusHCQ useHeart failureCardiac abnormalitiesCardiac magnetic resonance imagingDose-dependent complicationsRheumatoid arthritisCases of SLE patientsDiscontinuation of hydroxychloroquineResolution of symptomsLong-term therapyEarly detectionShortness of breathA-V blockHCQ therapyMagnetic resonance imagingPrompt discontinuationEndomyocardial biopsyPulmonary hypertensionEjection fractionHF therapyCardiac symptomsImprove patient outcomesSLE patientsSjogren's syndromeBeyond convention: non-compacted myocardium, ventricular tachycardia, and systolic dysfunction in dextrocardia patients: a case series
Nazarenko N, Maliha M, Cerna L, Abittan N, Borkowski P, Csecs I, Garcia M. Beyond convention: non-compacted myocardium, ventricular tachycardia, and systolic dysfunction in dextrocardia patients: a case series. Annals Of Medicine And Surgery 2025, 87: 56-61. PMID: 40109641, PMCID: PMC11918691, DOI: 10.1097/ms9.0000000000002855.Peer-Reviewed Original ResearchLeft ventricleDextrocardia patientsICD placementSeverely reduced ejection fractionHigh risk of sudden cardiac deathRight-sided pleural effusionRisk of sudden cardiac deathAbnormal myocardial developmentYears of follow-upNon-compacted myocardiumTreated with amiodaroneSubsegmental pulmonary embolismTreated with enoxaparinLong-term outcomesSudden cardiac deathSystolic dysfunctionEvent-freeWorsening dyspneaEjection fractionPulmonary embolismAtrial dilatationPleural effusionConduction abnormalitiesMedical therapyCase seriesCardiac MRI predicts mortality in patients with autoimmune rheumatic diseases
Csecs I, Tysarowski M, Baldassarre L, Feher A. Cardiac MRI predicts mortality in patients with autoimmune rheumatic diseases. Journal Of Cardiovascular Magnetic Resonance 2025, 27: 101317. DOI: 10.1016/j.jocmr.2024.101317.Peer-Reviewed Original Research
2024
Positron Emission Tomography in the Diagnosis and Management of Cardiac Allograft Vasculopathy
Csecs I, Yakkali S, Feher A. Positron Emission Tomography in the Diagnosis and Management of Cardiac Allograft Vasculopathy. Current Cardiovascular Imaging Reports 2024, 17: 85-92. DOI: 10.1007/s12410-024-09595-7.Peer-Reviewed Original ResearchManagement of CAVPositron emission tomography myocardial perfusion imagingCardiac allograft vasculopathyInvasive coronary angiographyMyocardial perfusion imagingMyocardial flow reservePositron emission tomographyHeart transplant recipientsMyocardial blood flowAllograft vasculopathyTransplant recipientsPET-derived MBFInternational Society for Heart and Lung Transplantation guidelinesCAV detectionAlternative to invasive coronary angiographyEfficacy of positron emission tomographyRoutine surveillance protocolEmission tomographyClass IIa indicationFrequent invasive proceduresReduce radiation exposurePositron emission tomography imagingPrognostic valueCoronary angiographyMulticenter studyIMPAIRED APICAL LONGITUDINAL STRAIN IS ASSOCIATED WITH ADVERSE EVENTS IN A MULTIETHNIC COHORT WITH APICAL HYPERTROPHIC CARDIOMYOPATHY
Csecs I, Lorenzatti D, Scotti A, Filtz A, Gongora C, Rodriguez C, Masri A, Moon J, Schenone A, Garcia M, Slipczuk L. IMPAIRED APICAL LONGITUDINAL STRAIN IS ASSOCIATED WITH ADVERSE EVENTS IN A MULTIETHNIC COHORT WITH APICAL HYPERTROPHIC CARDIOMYOPATHY. Journal Of The American College Of Cardiology 2024, 83: 1368. DOI: 10.1016/s0735-1097(24)03358-8.Peer-Reviewed Original ResearchHYDROXYCHLOROQUINE TROUBLES: THREE TOXIC TALES
Nazarenko N, Tauras J, Sims D, Shin J, Pullman J, Csecs I, Rochlani Y. HYDROXYCHLOROQUINE TROUBLES: THREE TOXIC TALES. Journal Of The American College Of Cardiology 2024, 83: 3580. DOI: 10.1016/s0735-1097(24)05570-0.Peer-Reviewed Original Research
2023
The fat and the flow: multiparametric imaging assessment of pericoronary adipose tissue and myocardial blood flow
Csecs I, Feher A. The fat and the flow: multiparametric imaging assessment of pericoronary adipose tissue and myocardial blood flow. Journal Of Nuclear Cardiology 2023, 30: 1570-1573. PMID: 36929294, DOI: 10.1007/s12350-023-03247-x.Peer-Reviewed Original ResearchCARDIOPULMONARY EXERCISE TESTING IS SAFE IN HYPERTROPHIC CARDIOMYOPATHY: INCIDENCE AND OUTCOMES OF SUSTAINED VENTRICULAR ARRHYTHMIAS IN A LARGE REFERRAL COHORT
Csecs I, Geske J, Garzona-Navas A, Klarich K, Ommen S, Allison T. CARDIOPULMONARY EXERCISE TESTING IS SAFE IN HYPERTROPHIC CARDIOMYOPATHY: INCIDENCE AND OUTCOMES OF SUSTAINED VENTRICULAR ARRHYTHMIAS IN A LARGE REFERRAL COHORT. Journal Of The American College Of Cardiology 2023, 81: 345. DOI: 10.1016/s0735-1097(23)00789-1.Peer-Reviewed Original ResearchRELATIONSHIP WITH INDUSTRY AND OTHER ENTITIES IN CURRENT CARDIOVASCULAR CLINICAL PRACTICE GUIDELINES
Csecs I, Abbott J, Thachil R, Kundu A, Chatterjee S, Sardar P, Faillace R. RELATIONSHIP WITH INDUSTRY AND OTHER ENTITIES IN CURRENT CARDIOVASCULAR CLINICAL PRACTICE GUIDELINES. Journal Of The American College Of Cardiology 2023, 81: 2292. DOI: 10.1016/s0735-1097(23)02736-5.Peer-Reviewed Original ResearchDoes Coronary Plaque Morphology Matter Beyond Plaque Burden?
Lorenzatti D, Piña P, Csecs I, Schenone A, Gongora C, Garcia M, Blaha M, Budoff M, Williams M, Dey D, Berman D, Virani S, Slipczuk L. Does Coronary Plaque Morphology Matter Beyond Plaque Burden? Current Atherosclerosis Reports 2023, 25: 167-180. PMID: 36808390, DOI: 10.1007/s11883-023-01088-0.Peer-Reviewed Original ResearchConceptsCoronary computed tomography angiographyMedical therapyPlaque burdenResponse to medical therapyPlaque analysisCoronary plaquesAssessment of coronary plaquesHigh-risk phenotypePreventive medical therapyAdverse cardiovascular eventsCoronary plaque featuresRandomized controlled trialsPericoronary inflammationMyocardial infarction typeCardiovascular eventsDisease progressionRisk phenotypesCulprit plaquesControlled trialsPlaque characteristicsPlaque featuresTherapySummaryThe identificationTracking disease progressionInfarct type
2022
Bezold–Jarisch reflex mediated syncope in pulmonary arterial hypertension: An illustrative case series
Agboola K, Kowlgi G, Csecs I, DuBrock H, Cajigas H, Allison T. Bezold–Jarisch reflex mediated syncope in pulmonary arterial hypertension: An illustrative case series. Pulmonary Circulation 2022, 12: e12147. PMID: 36325510, PMCID: PMC9618286, DOI: 10.1002/pul2.12147.Peer-Reviewed Original ResearchThe role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. The role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy. European Heart Journal 2022, 43: ehac544.272. DOI: 10.1093/eurheartj/ehac544.272.Peer-Reviewed Original ResearchFeature-tracking strain analysisCardiac magnetic resonanceLeft ventricular hypertrophyLV hypertrophyMyocardial diseaseHypertrophic cardiomyopathyEndomyocardial fibrosisBasal LSCardiac amyloidosisCA patientsVentricular hypertrophyGlobal dyssynchronyDifferential diagnosisLeft ventricular (LV) hypertrophyPatient populationCardiac magnetic resonance examinationLV stroke volume indexFabry diseasePrognostic assessment of patientsSignificant independent predictors of mortalityIndependent predictor of mortalityEndomyocardial fibrosis patientsLV strain parametersLV) hypertrophyLV strain analysisDiffuse Alveolar Hemorrhage as an Unusual Pulmonary Manifestation of Multisystem Inflammatory Syndrome in Adults
Hti Lar Seng N, Csecs I, Rojas M, Tiwari N, Faillace R. Diffuse Alveolar Hemorrhage as an Unusual Pulmonary Manifestation of Multisystem Inflammatory Syndrome in Adults. Annals Of Internal Medicine Clinical Cases 2022, 1 DOI: 10.7326/aimcc.2022.0447.Peer-Reviewed Original ResearchPotential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. Potential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis. PLOS ONE 2022, 17: e0269807. PMID: 35696411, PMCID: PMC9191721, DOI: 10.1371/journal.pone.0269807.Peer-Reviewed Original ResearchConceptsCardiac AL amyloidosisCardiac magnetic resonanceLate gadolinium enhancementAL amyloidosisOptimal diagnostic performanceHypertrophic cardiomyopathyDegree of left ventricular (LV) hypertrophyReduced global LV longitudinal strainDiagnostic performanceLeft ventricular (LV) hypertrophyPattern of late gadolinium enhancementGlobal LV longitudinal strainSubendocardial late gadolinium enhancementCardiac magnetic resonance examinationCardiac magnetic resonance parametersCardiac light-chain amyloidosisDifferential diagnosis of cardiomyopathyLV strain parametersCardiac transthyretin amyloidosisLV) hypertrophyLV longitudinal strainDiagnosis of cardiomyopathyLight chain amyloidosisCardiac light chainsPotential clinical relevanceReference CMR values of atrial size and function: Are they similar in the east and the west?
Csecs I, Garcia M. Reference CMR values of atrial size and function: Are they similar in the east and the west? International Journal Of Cardiology 2022, 358: 134-135. PMID: 35483479, DOI: 10.1016/j.ijcard.2022.02.036.Peer-Reviewed Original ResearchAn Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy
Fahmy A, Csecs I, Arafati A, Assana S, Yankama T, Al-Otaibi T, Rodriguez J, Chen Y, Ngo L, Manning W, Kwong R, Nezafat R. An Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy. JACC Cardiovascular Imaging 2022, 15: 766-779. PMID: 35033500, DOI: 10.1016/j.jcmg.2021.11.029.Peer-Reviewed Original ResearchConceptsNonischemic dilated cardiomyopathyBeth Israel Deaconess Medical CenterComposite endpointRight ventricular (RV) dysfunctionCardiovascular hospitalizationRisk prediction modelAdverse outcomesRisk markersMarker of adverse outcomeCardiac magnetic resonance markersRisk stratification of patientsRight ventricular dysfunctionRV ejection fractionMedical CenterFollow-up durationCardiac magnetic resonanceEnd-diastolic volumeStratification of patientsArea under the curveAll-cause deathHigh-risk thresholdVentricular dysfunctionEjection fractionNonischemic cardiomyopathyPrognostic significance
2021
Benchmarking off-the-shelf statistical shape modeling tools in clinical applications
Goparaju A, Iyer K, Bône A, Hu N, Henninger H, Anderson A, Durrleman S, Jacxsens M, Morris A, Csecs I, Marrouche N, Elhabian S. Benchmarking off-the-shelf statistical shape modeling tools in clinical applications. Medical Image Analysis 2021, 76: 102271. PMID: 34974213, PMCID: PMC8792348, DOI: 10.1016/j.media.2021.102271.Peer-Reviewed Original ResearchConceptsStatistical shape modelShape modelPopulation-level variabilityDevelopment of open-source computational toolsAnalysis of anatomical shapesEvaluating shape modelsSurface correspondenceQualitative metricsSPHARM-PDMMorphometric approachOpen-source computational toolsValidation frameworkGroupwise approachClinical applicationModeling toolsLevel of consistencyPopulation-level statisticsDeformetricaThe role of feature-tracking strain analysis in the differentiation of cardiac amyloidosis from hypertrophic cardiomyopathy
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. The role of feature-tracking strain analysis in the differentiation of cardiac amyloidosis from hypertrophic cardiomyopathy. European Heart Journal 2021, 42: ehab724.0240. DOI: 10.1093/eurheartj/ehab724.0240.Peer-Reviewed Original ResearchCardiac involvement of amyloidosisLeft ventricular ejection fractionLate gadolinium enhancementCardiac magnetic resonanceAmount of late gadolinium enhancementHypertrophic cardiomyopathy patientsFeature-tracking strain analysisCA patientsHypertrophic cardiomyopathyBasal LSDiagnostic accuracyPattern of late gadolinium enhancementCardiac magnetic resonance diagnosisCardiac magnetic resonance examinationSignificant independent predictors of mortalityCox proportional hazards regression analysisIndependent predictor of mortalityLV strain parametersRegional strain valuesYears of follow-upProportional hazards regression analysisVentricular ejection fractionOptimal cutoff valueLog-rank testDiagnosis of CACharacterization of Aerosol Generation During Various Intensities of Exercise
Sajgalik P, Garzona-Navas A, Csécs I, Askew J, Lopez-Jimenez F, Niven A, Johnson B, Allison T. Characterization of Aerosol Generation During Various Intensities of Exercise. CHEST Journal 2021, 160: 1377-1387. PMID: 33957100, PMCID: PMC8473677, DOI: 10.1016/j.chest.2021.04.041.Peer-Reviewed Original ResearchConceptsHeart rate reserveRate reservePredicted heart rate reserveExercise testSafety of exercise testingPeak respiratory exchange ratioIntensity of exercisePeak heart rateRespiratory exchange ratioStages of exerciseExercise intensityExercise activitiesMaximal ventilationExchange ratioExerciseAerosol-generating proceduresActivity recoveryStatistically significant increaseSafety recommendationsHealthy volunteersFace of COVID-19Heart rateSignificant increaseRecommendationsCOVID-19Mitigation of Aerosols Generated During Exercise Testing With a Portable High-Efficiency Particulate Air Filter With Fume Hood
Garzona-Navas A, Sajgalik P, Csécs I, Askew J, Lopez-Jimenez F, Niven A, Johnson B, Allison T. Mitigation of Aerosols Generated During Exercise Testing With a Portable High-Efficiency Particulate Air Filter With Fume Hood. CHEST Journal 2021, 160: 1388-1396. PMID: 33895130, PMCID: PMC8463654, DOI: 10.1016/j.chest.2021.04.023.Peer-Reviewed Original ResearchConceptsExercise testing laboratoryPortable HEPA filterExercise testPortable high-efficiency particulate airAerosol concentrationsClearance timeConcentration of aerosolsExercise experienceStationary cyclingRisk of COVID-19 transmissionExerciseActivity recoveryHealthy volunteersAerosolQuiet breathingAerosol mitigationParticle counterAerosol clearanceClearance experimentsCOVID-19 pandemicCOVID-19 transmissionParticle concentrationLarger particlesCOVID-19
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