A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation
Vittoria M, Shenk E, O’Rourke K, Bolgioni A, Lim S, Kacprzak V, Quinton R, Ganem N. A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation. Molecular Biology Of The Cell 2018, 29: 1682-1692. PMID: 29791254, PMCID: PMC6080710, DOI: 10.1091/mbc.e18-02-0141.Peer-Reviewed Original ResearchConceptsTetraploid cellsGenome-wide screenRecent genomic studiesTumor suppressor pathwayP53 tumor suppressor pathwayProliferative capacityP53/p21 pathwayGenomic studiesHippo pathwayCell divisionMicroRNA screenGenetic routesSuppressor pathwaySingle miRNATumor suppressor gene NF2Nontransformed cellsHuman cancersP21 pathwayCell proliferationTumor developmentGene NF2PathwayMiRNAComprehensive gainProliferation
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