Featured Publications
Inactivation of the Hippo tumor suppressor pathway promotes melanoma
Vittoria M, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell J, Lang D, Xu X, Ceol C, Varelas X, Ganem N. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nature Communications 2022, 13: 3732. PMID: 35768444, PMCID: PMC9243107, DOI: 10.1038/s41467-022-31399-w.Peer-Reviewed Original Research
2019
Identification of the kinase STK25 as an upstream activator of LATS signaling
Lim S, Hermance N, Mudianto T, Mustaly H, Mauricio I, Vittoria M, Quinton R, Howell B, Cornils H, Manning A, Ganem N. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nature Communications 2019, 10: 1547. PMID: 30948712, PMCID: PMC6449379, DOI: 10.1038/s41467-019-09597-w.Peer-Reviewed Original ResearchConceptsHippo signalingHippo pathwayHippo tumor suppressor pathwayTranscriptional co-activator YAPActivation loop phosphorylationCo-activator YAPCore pathway componentsYAP/TAZ activationTumor suppressor pathwayKey unresolved questionLoop phosphorylationHippo activationPhosphorylation eventsHydrophobic motifTissue homeostasisTAZ activationUpstream activatorKinase activatorPathway componentsSuppressor pathwaySTK25Human cancersFunctional inactivationCellular proliferationSignaling
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