Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
Quinton R, DiDomizio A, Vittoria M, Kotýnková K, Ticas C, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda T, Parulekar N, Taylor A, Manning A, Campbell J, Ganem N. Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature 2021, 590: 492-497. PMID: 33505027, PMCID: PMC7889737, DOI: 10.1038/s41586-020-03133-3.Peer-Reviewed Original ResearchConceptsWhole-genome doublingUnstable tetraploid cellsAccurate chromosome segregationDNA replication factorsSpindle assembly checkpointPrimary human cancer samplesHuman cancer samplesEssentiality dataChromosome segregationUnique genetic vulnerabilitiesTetraploid stateKinesin proteinsProteasome functionMitotic errorsGenetic traitsTetraploid cellsHuman cancersCancer cell linesCancer cellsCell linesKIF18ACell viabilityCancer samplesHuman tissuesCells
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