Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic–Epigenetic Cross-Talk
Greenwood D, Ramsey H, Nguyen P, Patterson A, Voss K, Bader J, Sugiura A, Bacigalupa Z, Schaefer S, Ye X, Dahunsi D, Madden M, Wellen K, Savona M, Ferrell P, Rathmell J. Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic–Epigenetic Cross-Talk. ImmunoHorizons 2022, 6: 837-850. PMID: 36547387, PMCID: PMC9935084, DOI: 10.4049/immunohorizons.2200086.Peer-Reviewed Original ResearchConceptsChromatin accessibilityMyeloid differentiationTransposase-accessible chromatin sequencingEpigenetic cross talkHematopoietic stemSingle-cell RNA sequencingFamily transcription factorsProgenitor cellsSmall molecule inhibitionSingle-cell assaysATP-citrate lyaseEpigenetic marksAcetyl coenzyme AGene expression signaturesEpigenetic modificationsTranscription factorsRNA sequencingACLY inhibitionMitochondrial metabolismReactive oxygen speciesMitochondrial polarizationMurine hematopoiesisCell metabolismMus musculusEssential substrate
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