Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation
Chowdhury N, Cephus J, Pilier E, Wolf M, Madden M, Kuehnle S, McKernan K, Jennings E, Arner E, Heintzman D, Chi C, Sugiura A, Stier M, Voss K, Ye X, Scales K, Krystofiak E, Gandhi V, Guzy R, Cahill K, Sperling A, Peebles R, Rathmell J, Newcomb D. Androgen signaling restricts glutaminolysis to drive sex-specific Th17 metabolism in allergic airway inflammation. Journal Of Clinical Investigation 2024, 134: e177242. PMID: 39404231, PMCID: PMC11601904, DOI: 10.1172/jci177242.Peer-Reviewed Original ResearchTh17 cellsAirway inflammationAR signalingT cellsAndrogen receptorTh17-mediated airway inflammationAirway inflammation mouse modelCD4+ T cellsExpression of glutamine transportersCirculating T cellsRegulation of Th17 cellsAllergic airway inflammationCell-mediated diseasesGlutamine uptakeInflammation mouse modelAndrogen signalingMouse modelTh17Increased prevalenceReduced expressionInflammationAndrogenGlutamine transportGlutaminolysisDecreased glutaminolysis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply