Featured Publications
Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells.
Madden M, Ye X, Chi C, Fisher E, Wolf M, Needle G, Bader J, Patterson A, Reinfeld B, Landis M, Hathaway E, Muka J, O'Neil R, Karijolich J, Philip M, Rathmell J. Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells. The Journal Of Immunology 2023, 211: 563-575. PMID: 37341499, PMCID: PMC10526752, DOI: 10.4049/jimmunol.2200715.Peer-Reviewed Original ResearchConceptsCD8 T cellsT cellsActivated T cellsAntitumor CD8 T cellsCD8 T cell differentiationAdoptive transfer studiesMurine CD8 T cellsQ treatmentAdoptive cell therapyT cell functionT cell dependenceT cell differentiationT cell activationCB-839 treatmentAutoimmune diseasesFunctional outcomeTumor infiltrationTreatment strategiesGlucose metabolismCell activationTumor growthCB-839Cell therapyCell functionOxidative metabolism
2018
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
Johnson M, Wolf M, Madden M, Andrejeva G, Sugiura A, Contreras D, Maseda D, Liberti M, Paz K, Kishton R, Johnson M, de Cubas A, Wu P, Li G, Zhang Y, Newcomb D, Wells A, Restifo N, Rathmell W, Locasale J, Davila M, Blazar B, Rathmell J. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. Cell 2018, 175: 1780-1795.e19. PMID: 30392958, PMCID: PMC6361668, DOI: 10.1016/j.cell.2018.10.001.Peer-Reviewed Original ResearchConceptsCell differentiationDistinct metabolic programsAltered chromatin accessibilityTricarboxylic acid cycleChromatin accessibilityEpigenetic reactionsCell activationMetabolic programsGene expressionDistinct regulationAcid cycleGLS inhibitionTh1 cellsGlutamine metabolismDistinct rolesImpaired differentiationElevated functionEffector cell differentiationDifferentiationTh1 cell differentiationCell numberCellsCD4 Th1Th17 cellsInflammatory diseases
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