2022
Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic–Epigenetic Cross-Talk
Greenwood D, Ramsey H, Nguyen P, Patterson A, Voss K, Bader J, Sugiura A, Bacigalupa Z, Schaefer S, Ye X, Dahunsi D, Madden M, Wellen K, Savona M, Ferrell P, Rathmell J. Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic–Epigenetic Cross-Talk. ImmunoHorizons 2022, 6: 837-850. PMID: 36547387, PMCID: PMC9935084, DOI: 10.4049/immunohorizons.2200086.Peer-Reviewed Original ResearchConceptsChromatin accessibilityMyeloid differentiationTransposase-accessible chromatin sequencingEpigenetic cross talkHematopoietic stemSingle-cell RNA sequencingFamily transcription factorsProgenitor cellsSmall molecule inhibitionSingle-cell assaysATP-citrate lyaseEpigenetic marksAcetyl coenzyme AGene expression signaturesEpigenetic modificationsTranscription factorsRNA sequencingACLY inhibitionMitochondrial metabolismReactive oxygen speciesMitochondrial polarizationMurine hematopoiesisCell metabolismMus musculusEssential substrate
2018
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
Johnson M, Wolf M, Madden M, Andrejeva G, Sugiura A, Contreras D, Maseda D, Liberti M, Paz K, Kishton R, Johnson M, de Cubas A, Wu P, Li G, Zhang Y, Newcomb D, Wells A, Restifo N, Rathmell W, Locasale J, Davila M, Blazar B, Rathmell J. Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. Cell 2018, 175: 1780-1795.e19. PMID: 30392958, PMCID: PMC6361668, DOI: 10.1016/j.cell.2018.10.001.Peer-Reviewed Original ResearchConceptsCell differentiationDistinct metabolic programsAltered chromatin accessibilityTricarboxylic acid cycleChromatin accessibilityEpigenetic reactionsCell activationMetabolic programsGene expressionDistinct regulationAcid cycleGLS inhibitionTh1 cellsGlutamine metabolismDistinct rolesImpaired differentiationElevated functionEffector cell differentiationDifferentiationTh1 cell differentiationCell numberCellsCD4 Th1Th17 cellsInflammatory diseases
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