Cell-programmed nutrient partitioning in the tumour microenvironment
Reinfeld B, Madden M, Wolf M, Chytil A, Bader J, Patterson A, Sugiura A, Cohen A, Ali A, Do B, Muir A, Lewis C, Hongo R, Young K, Brown R, Todd V, Huffstater T, Abraham A, O’Neil R, Wilson M, Xin F, Tantawy M, Merryman W, Johnson R, Williams C, Mason E, Mason F, Beckermann K, Vander Heiden M, Manning H, Rathmell J, Rathmell W. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature 2021, 593: 282-288. PMID: 33828302, PMCID: PMC8122068, DOI: 10.1038/s41586-021-03442-1.Peer-Reviewed Original ResearchConceptsPositron emission tomographyTumor microenvironmentCancer cellsImmune cellsCell-intrinsic programsTumor-infiltrating immune cellsGlucose uptakeBasis of tumorImmune cell metabolismCell-intrinsic mannerSpecific cell subsetsEnhanced glucose uptakeCell subsetsMetabolism of glucoseT cellsImmune evasionUptake of glucoseCancer modelMyeloid cellsEmission tomographyPET tracersSpecific cell populationsCell populationsHigh uptakeGlutamine metabolism
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