2023
STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy
Wang-Bishop L, Kimmel B, Ngwa V, Madden M, Baljon J, Florian D, Hanna A, Pastora L, Sheehy T, Kwiatkowski A, Wehbe M, Wen X, Becker K, Garland K, Schulman J, Shae D, Edwards D, Wolf M, Delapp R, Christov P, Beckermann K, Balko J, Rathmell W, Rathmell J, Chen J, Wilson J. STING-activating nanoparticles normalize the vascular-immune interface to potentiate cancer immunotherapy. Science Immunology 2023, 8: eadd1153. PMID: 37146128, PMCID: PMC10226150, DOI: 10.1126/sciimmunol.add1153.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalHumansImmunotherapyMiceNanoparticlesNeoplasmsT-LymphocytesTumor MicroenvironmentConceptsSTING-activating nanoparticlesT cell infiltrationCell infiltrationT cellsAdoptive T-cell therapyMultiple mouse tumor modelsT-cell adhesion moleculesImmune checkpoint inhibitorsEffector T cellsAntitumor T cellsT-cell therapyEffective tumor controlCyclic dinucleotide STING agonistsEndothelial cell expressionTumor-associated vasculatureMouse tumor modelsCheckpoint inhibitorsCancer immunotherapyTumor controlVascular normalizationIntravenous administrationCell adhesion moleculeAntitumor functionSTING agonistsCell expression
2022
Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer
Glass E, Hoover A, Bullock K, Madden M, Reinfeld B, Harris W, Parker D, Hufnagel D, Crispens M, Khabele D, Rathmell W, Rathmell J, Wilson A, Giorgio T, Yull F. Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer. BMC Cancer 2022, 22: 497. PMID: 35513776, PMCID: PMC9074180, DOI: 10.1186/s12885-022-09612-2.Peer-Reviewed Original ResearchConceptsTumor-associated macrophagesAnti-tumor immunityOvarian cancerConsecutive days' treatmentTumor burdenMouse modelSolid tumorsImmunosuppressive tumor-associated macrophagesAnti-tumor phenotypeLate-stage diseaseClear therapeutic effectImmune cell compositionImmunosuppressive tumor microenvironmentM1 macrophage polarizationStrong translational potentialOvarian cancer modelFuture clinical studiesNF-κB alphaOvarian cancer progressionHigh response rateNF-κB activityEvidence of toxicityNuclear factor-kappaBInducible transgenic miceID8 model
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