VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis
Wolf M, Madden M, Arner E, Bader J, Ye X, Vlach L, Tigue M, Landis M, Jonker P, Hatem Z, Steiner K, Gaines D, Reinfeld B, Hathaway E, Xin F, Tantawy M, Haake S, Jonasch E, Muir A, Weiss V, Beckermann K, Rathmell W, Rathmell J. VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis. Journal Of Clinical Investigation 2024, 134: e173934. PMID: 38618956, PMCID: PMC11014672, DOI: 10.1172/jci173934.Peer-Reviewed Original ResearchConceptsClear cell renal cell carcinomaTumor-associated macrophagesVon Hippel-LindauImmune landscapeTumor microenvironmentVon Hippel-Lindau lossVHL-KOImmune cellsAnti-programmed cell death 1VHL lossInflammatory transcriptional signaturesTumor immune landscapeCell death 1Cell renal cell carcinomaRenal cell carcinomaHuman ccRCC tumorsTreatment of clear cell renal cell carcinomaMyeloid microenvironmentDeath-1RENCA modelCell carcinomaCcRCC tumorsLymphoid cellsChemokine CX3CL1Renal tumorigenesis
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