Divergent CFTR orthologs respond differently to the channel inhibitors CFTRinh-172, glibenclamide, and GlyH-101
Stahl M, Stahl K, Brubacher MB, Forrest JN. Divergent CFTR orthologs respond differently to the channel inhibitors CFTRinh-172, glibenclamide, and GlyH-101. American Journal Of Physiology - Cell Physiology 2011, 302: c67-c76. PMID: 21940661, PMCID: PMC3328903, DOI: 10.1152/ajpcell.00225.2011.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorGlyH-101Expression studiesChannel proteinsCFTR chloride channel proteinFibrosis transmembrane conductance regulatorChloride channel proteinSite-directed mutagenesisShark rectal glandAmino acid residuesTransmembrane conductance regulatorDifferent orthologsSingle amino acidPrevious site-directed mutagenesisOocyte expression studiesThree-dimensional structureRegulatory regionsXenopus laevis oocytesCFTR proteinAdditional residuesConductance regulatorOrthologsAcid residuesRectal glandSpecific inhibitor
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