Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial
Krishnan-Sarin S, O’Malley S, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology 2019, 45: 319-326. PMID: 31590179, PMCID: PMC6901445, DOI: 10.1038/s41386-019-0536-z.Peer-Reviewed Original ResearchConceptsAlcohol drinking behaviorFirst treatment periodTreatment periodNumber of drinksCrossover trialDrinking behaviorEfficacy of naltrexoneOpioid antagonist naltrexoneNMDA antagonist memantinePositive family historyDay treatment periodSelf-administration periodAlcohol-induced stimulationAd lib accessMemantine treatmentAntagonist naltrexoneOpioid systemFamily historyNTXPriming drinkMemantineNaltrexoneAlcohol cravingHeavy drinkersAlcohol dependenceDoes Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol?
Berey BL, Leeman RF, Pittman B, Franco N, Krishnan-Sarin S. Does Self-Reported or Behavioral Impulsivity Predict Subjective Response to Low-Dose Alcohol? Alcohol And Alcoholism 2019, 54: 180-187. PMID: 30649160, PMCID: PMC6476413, DOI: 10.1093/alcalc/agy092.Peer-Reviewed Original ResearchConceptsLow-dose alcoholBlood alcohol concentrationAlcohol use disorderHeavy drinkersSubjective responsesTrend-level predictorNMDA receptor antagonistBiphasic Alcohol Effects ScaleAlcohol administration studyIndependent predictorsReceptor antagonistRisk factorsUse disordersSubjective stimulationGo/No-Go taskMore impulsive individualsHigh dosesEffects ScaleSedationAlcohol useSubjective effectsAdministration studiesImpulsivity measuresBarratt Impulsiveness ScaleDrinking occasions
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