Featured Publications
Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases
Zhao J, Ong C, Srivastava S, Chia D, Ma H, Huang K, Sheng T, Ramnarayanan K, Ong X, Tay S, Hagihara T, Tan A, Teo M, Tan Q, Ng G, Tan J, Ng M, Gwee Y, Walsh R, Law J, Shabbir A, Kim G, Tay Y, Her Z, Leoncini G, Teh B, Hong J, Tay R, Teo C, Dings M, Bijlsma M, Lum J, Mathur S, Pietrantonio F, Blum S, van Laarhoven H, Klempner S, Yong W, So J, Chen Q, Tan P, Sundar R. Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases. Gastroenterology 2024, 167: 1384-1398.e4. PMID: 39147169, DOI: 10.1053/j.gastro.2024.08.007.Peer-Reviewed Original ResearchPeritoneal metastasisTumor microenvironmentPrimary tumorTranscoelomic metastasisGastric cancerExpression of therapeutic targetsAssociated with poor prognosisGastric cancer peritoneal metastasisAssociated with increased riskHumanized mouse modelTherapeutic targetComprehensive multi-omics analysisTumor microenvironment signaturesTumor microenvironment alterationsDigital spatial profilingInvestigate molecular alterationsWhole-exome sequencingMatched normal tissuesStromal infiltrationComprehensive molecular characterizationLiver metastasesImmune compositionFGFR2b expressionImprove patient outcomesPredictive marker
2025
Diverse stromal phenotypes at spatial resolution in colorectal cancer peritoneal metastasis.
Zhao J, Ong J, Liu Y, Srivastava S, Teo M, Lee J, Walsh R, Loo L, Tan Q, Ng G, Tan J, Ma H, Ong X, Tay S, Sheng T, Lum J, Yong W, Pietrantonio F, Tan P, Sundar R. Diverse stromal phenotypes at spatial resolution in colorectal cancer peritoneal metastasis. Journal Of Clinical Oncology 2025, 43: 218-218. DOI: 10.1200/jco.2025.43.4_suppl.218.Peer-Reviewed Original ResearchCancer-associated fibroblastsT cell exhaustionPeritoneal metastasisT cellsStromal phenotypeColorectal cancerTissue microarrayStromal compartmentPoor prognosisSpatial distribution of T cellsColorectal cancer peritoneal metastasesIncreased CAFsClusters of T cellsCRC PMDistribution of T cellsTumor stroma compartmentAssociated with poor prognosisMemory B cellsDigital spatial profilingTranscoelomic disseminationTumor compartmentsStromal clustersPrognostic significanceTNF-alphaB cells
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