Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing
Cleary C, Milla B, Kuo F, James S, Flynn W, Robson P, Mulkey D. Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing. ELife 2021, 10: e60317. PMID: 34013884, PMCID: PMC8169115, DOI: 10.7554/elife.60317.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideChemoreceptor CellsDisease Models, AnimalEpilepsies, MyoclonicFemaleGlutamic AcidHydrogenIntralaminar Thalamic NucleiLungMaleMice, 129 StrainMice, Inbred C57BLMice, TransgenicNAV1.1 Voltage-Gated Sodium ChannelNeural InhibitionRespirationSomatostatinSynaptic TransmissionConceptsParafacial neuronsRTN chemoreceptorsBaseline breathingParafacial regionInhibitory neuronsInhibitory synaptic interactionsInhibitory neural activityRTN chemoreceptionRTN neuronsChemogenetic suppressionDravet syndromeGlutamatergic neuronsInhibitory inputsMouse modelRespiratory chemoreceptorsSynaptic propertiesSynaptic interactionsTissue CONeuronsBreathingContext of diseaseNeural activityDependent mannerChemoreceptorsNucleus function
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