2017
mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions
Jin L, Wang M, Yang S, Yang Y, Galvin V, Lightbourne T, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas C, Arnsten A. mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. Molecular Psychiatry 2017, 22: 1511-1511. DOI: 10.1038/mp.2017.206.Peer-Reviewed Original ResearchPrimate dorsolateral prefrontal cortexDorsolateral prefrontal cortexPostsynaptic actionsPrefrontal cortexCortex
2016
mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions
Jin LE, Wang M, Yang ST, Yang Y, Galvin VC, Lightbourne TC, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas CD, Arnsten AFT. mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. Molecular Psychiatry 2016, 22: 1615-1625. PMID: 27502475, PMCID: PMC5298940, DOI: 10.1038/mp.2016.129.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexLow dosesPostsynaptic actionsGroup II metabotropic glutamate receptorsN-methyl-D-aspartate receptorsPrefrontal cortexPrimate dorsolateral prefrontal cortexGlial glutamate uptakeMetabotropic glutamate receptorsAge-related disordersAstrocytic locationGlutamate releaseIontophoretic applicationClinical trialsSystemic administrationGlutamate receptorsTherapeutic effectGlutamate uptakeDendritic spinesNeuronal firingTherapeutic interventionsHigh dosesPostsynaptic cAMPSynaptic connectionsCognitive deficits
2014
Neuronal representation of working memory in the medial prefrontal cortex of rats
Yang S, Shi Y, Wang Q, Peng J, Li B. Neuronal representation of working memory in the medial prefrontal cortex of rats. Molecular Brain 2014, 7: 61. PMID: 25159295, PMCID: PMC4237901, DOI: 10.1186/s13041-014-0061-2.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexMPFC cellsPrefrontal cortexKey cortical regionsDorsolateral prefrontal cortexWorking-memory tasksMPFC neuronsPerformance of ratsNeuronal activityCortical areasAnatomical connectionsAlternation taskCortical regionsRatsY-mazeNeurophysiological studiesCortexDischarge frequencyNeuronal representationsBehavioral performanceNeuronsEarly phasePresent studyMonkeysCells
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