mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions
Jin LE, Wang M, Yang ST, Yang Y, Galvin VC, Lightbourne TC, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas CD, Arnsten AFT. mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. Molecular Psychiatry 2016, 22: 1615-1625. PMID: 27502475, PMCID: PMC5298940, DOI: 10.1038/mp.2016.129.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexLow dosesPostsynaptic actionsGroup II metabotropic glutamate receptorsN-methyl-D-aspartate receptorsPrefrontal cortexPrimate dorsolateral prefrontal cortexGlial glutamate uptakeMetabotropic glutamate receptorsAge-related disordersAstrocytic locationGlutamate releaseIontophoretic applicationClinical trialsSystemic administrationGlutamate receptorsTherapeutic effectGlutamate uptakeDendritic spinesNeuronal firingTherapeutic interventionsHigh dosesPostsynaptic cAMPSynaptic connectionsCognitive deficits
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