Antioxidant Efficacy of Hwangryunhaedok-tang through Nrf2 and AMPK Signaling Pathway against Neurological Disorders In Vivo and In Vitro
Bae S, Lee W, Bak S, Lee S, Hwang S, Kim G, Koo B, Park S, Yoo H, Kim C, Kang H, Oh T, Kim Y. Antioxidant Efficacy of Hwangryunhaedok-tang through Nrf2 and AMPK Signaling Pathway against Neurological Disorders In Vivo and In Vitro. International Journal Of Molecular Sciences 2024, 25: 2313. PMID: 38396988, PMCID: PMC10889506, DOI: 10.3390/ijms25042313.Peer-Reviewed Original ResearchConceptsFormation of neurofibrillary tanglesNeurofibrillary tanglesAlzheimer's diseaseImpaired clearance of amyloid betaSignaling pathwayClearance of amyloid betaAMPK signaling pathwayActivate signaling pathwaysAlzheimer's disease in vivoInhibition of cell apoptosisCause of dementiaAmyloid-betaHT-22 cellsNeuritic plaquesIn vitroMitochondrial dysfunctionOxidative stressCell apoptosisDisease in vivoROS generationHT-22Prevent ADAMPKDisorders in vivoProtein levels
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