IL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer
Zhang Z, Chen Y, Pan X, Li P, Ren Z, Wang X, Chen Y, Shen S, Wang T, Lin A. IL-1β mediates Candida tropicalis-induced immunosuppressive function of MDSCs to foster colorectal cancer. Cell Communication And Signaling 2024, 22: 408. PMID: 39164774, PMCID: PMC11337875, DOI: 10.1186/s12964-024-01771-y.Peer-Reviewed Original ResearchConceptsImmunosuppressive function of MDSCsFunction of MDSCsExpression of IL-1bImmunosuppressive functionC. tropicalisColorectal cancerIL-1BProgression of colorectal cancerAntitumor immunityNLRP3 inflammasome activationColon cancer xenograft modelTumor-infiltrating MDSCsInhibit antitumor immunityPotential immunotherapeutic strategyRegulating tumor immunityTreatment of colorectal cancerSeverity of colorectal cancerCancer xenograft modelColon cancer cell linesInflammasome activationHuman colorectal cancerNLRP3 inflammasomeIn vitro supplementationImmunotherapeutic strategiesPromote CRC progression
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