Somatic Mutation of BAP1 Can Lead to Expression Loss in Non-Small Cell Lung Carcinoma: Next Generation Sequencing and IHC Analysis in A Large Single Institute Cohort
Sun T, Wang X, Wang M, Minerowicz C, Sanchez H, Laskin W, Cohen P, Zhong M. Somatic Mutation of BAP1 Can Lead to Expression Loss in Non-Small Cell Lung Carcinoma: Next Generation Sequencing and IHC Analysis in A Large Single Institute Cohort. International Journal Of Surgical Pathology 2021, 30: 512-519. PMID: 34970936, DOI: 10.1177/10668969211070179.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCarcinoma, Non-Small-Cell LungHigh-Throughput Nucleotide SequencingHumansImmunohistochemistryLungLung NeoplasmsMesothelioma, MalignantMutationTumor Suppressor ProteinsUbiquitin ThiolesteraseConceptsNon-small cell lung carcinomaCell lung carcinomaLung carcinomaCell carcinomaSomatic mutationsClear cell renal cell carcinomaExpression lossCell renal cell carcinomaSquamous cell carcinomaNext-generation sequencingGenetic alterationsRenal cell carcinomaBAP1 protein expressionProtein expression statusStudy cohortNSCLC casesNSCLC tumorsLoss of expressionNeural tumorsAdditional genetic alterationsCommon findingIHC analysisNSCLC carcinogenesisIRB approvalMelanocytic tumors
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