2025
An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy
Schrank B, Wang Y, Wu A, Tran N, Lee D, Edwards J, Huntoon K, Dong S, Ha J, Ma Y, Grippin A, Jeong S, Antony A, Chang M, Kang M, Gallup T, Koong A, Li J, Yun K, Kim B, Jiang W. An antibody–toxin conjugate targeting CD47 linked to the bacterial toxin listeriolysin O for cancer immunotherapy. Nature Cancer 2025, 6: 511-527. PMID: 40000910, DOI: 10.1038/s43018-025-00919-0.Peer-Reviewed Original ResearchConceptsAntibody-toxin conjugatesTumor cellsImmune recognition of tumor cellsEnhanced antigen cross-presentationRecognition of tumor cellsCancer cell phagocytosisTumor-derived antigensToxin listeriolysin OTumor-derived peptidesImproved animal survivalPromote immune recognitionCytosolic immune sensorsIntracellular bacterium Listeria monocytogenesTreatment in vivoTreating multiple cancersPhagocytosis checkpointsCheckpoint blockadeCancer immunotherapySignal CD47Listeriolysin OMetastatic breastMelanoma tumorsTherapeutic strategiesAnimal survivalCell phagocytosis
2024
Understanding nanoparticle-liver interactions in nanomedicine
He Y, Wang Y, Wang L, Jiang W, Wilhelm S. Understanding nanoparticle-liver interactions in nanomedicine. Expert Opinion On Drug Delivery 2024, 21: 829-843. PMID: 38946471, PMCID: PMC11281865, DOI: 10.1080/17425247.2024.2375400.Peer-Reviewed Original ResearchConceptsLiver Kupffer cellsNanoparticle physicochemical propertiesEnhanced delivery efficiencyAdministered nanoparticlesEffective nanomedicinesKupffer cellsLiver diseasePhagocytic functionClinical translationHepatic diseaseLiver accumulationClinical applicationNanomedicineDelivery efficiencyLiverPhagocytic roleDisease
2023
Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics
Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank B, Ha J, Kang M, Yang M, Gong P, Lorenzi P, Tan L, Gallup T, Tang S, Yang Z, Li J, Sanford N, Wang H, Kim B, Jiang W. Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics. Nature Nanotechnology 2023, 19: 255-263. PMID: 37723279, DOI: 10.1038/s41565-023-01502-3.Peer-Reviewed Original ResearchConceptsCancer nanotherapeuticsCancer nanomedicineScavenger receptor MARCOPhagocytic clearanceUptake of nanoparticlesAntitumour responseTumor deliveryTherapeutic blockadeAntitumour efficacyAge-associated decreaseHepatic phagocytesAntitumour effectsYoung miceHepatic macrophagesAged miceTreatment outcomesTreat multiple human diseasesProtein level analysisHepatic uptakeAge-related declineNon-human primatesNanotherapeuticsMiceNanomedicinePhagocytic uptakeIntradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy
You Y, Tian Y, Yang Z, Shi J, Kwak K, Tong Y, Estania A, Cao J, Hsu W, Liu Y, Chiang C, Schrank B, Huntoon K, Lee D, Li Z, Zhao Y, Zhang H, Gallup T, Ha J, Dong S, Li X, Wang Y, Lu W, Bahrani E, Lee L, Teng L, Jiang W, Lan F, Kim B, Lee A. Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy. Nature Biomedical Engineering 2023, 7: 887-900. PMID: 36635419, DOI: 10.1038/s41551-022-00989-w.Peer-Reviewed Original ResearchConceptsExtracellular vesiclesTranslation of genetic materialFunctional proteinsGenetic materialIntradermal deliveryRNA therapeuticsPhotoaged skinHuman dermal fibroblastsType I collagenMessenger RNA therapeuticsProtein replacement therapyTreatment of photoaged skinCOL1A1 mRNAVesiclesMRNADermal fibroblastsTissues of miceEncapsulated mRNAReduced wrinkle formationProteinTherapyDelivery systemReplacement of collagenMicroneedle arraysCollagen
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