Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice
Wu Y, Chang Y, Stell A, Priestnall S, Sharma E, Goulart M, Gribben J, Xia D, Garden O. Phenotypic characterisation of regulatory T cells in dogs reveals signature transcripts conserved in humans and mice. Scientific Reports 2019, 9: 13478. PMID: 31530890, PMCID: PMC6748983, DOI: 10.1038/s41598-019-50065-8.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsT cells isolated ex vivoSubsets of TregsTranscriptomic signaturesAvailability of mAbsHealthy dogsTreg functionMurine TregsVeterinary speciesTregsRegulatory phenotypeNeoplastic disordersSurface antigensImmune systemMonoclonal antibodiesDogsCross-species comparisonsMicePhenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells
Goulart M, Hlavaty S, Chang Y, Polton G, Stell A, Perry J, Wu Y, Sharma E, Broxholme J, Lee A, Szladovits B, Turmaine M, Gribben J, Xia D, Garden O. Phenotypic and transcriptomic characterization of canine myeloid-derived suppressor cells. Scientific Reports 2019, 9: 3574. PMID: 30837603, PMCID: PMC6400936, DOI: 10.1038/s41598-019-40285-3.Peer-Reviewed Original ResearchConceptsMyeloid-derived suppressor cellsPMN-MDSCsM-MDSCsSuppressor cellsMyeloid-derived suppressor cell subsetsMyeloid derived suppressor cell functionPeripheral blood frequenciesPolymorphonuclear (PMN)-MDSCsMonocytic (M)-MDSCsPhenotypically distinct subsetsHuman tumor developmentCanine oncology patientsTumor progressionImmune evasionTumor developmentContext of cancerOncology patientsTranscriptomic signaturesGene expression patternsPathological statesCancerExpression patternsCellsMetastasisSubsets
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