Yoshitaka Kimura
Associate Research ScientistCards
About
Titles
Associate Research Scientist
Education & Training
- Associate Research Scientist
- Yale University School of Medicine
- Postdoctoral Fellow
- Yale University School of Medicine (2022)
- Project Researcher
- The University of Tokyo (2018)
- PhD
- The University of Tokyo, Pharmaceutical Sciences (2016)
- MS
- The University of Tokyo, Pharmaceutical Sciences (2013)
- BS
- The University of Tokyo, Pharmaceutical Sciences (2011)
Research
Publications
2024
Mechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasis
2021
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells.
Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells. Nat Immunol 2021, 22: 947-957. PMID: 34239121, DOI: 10.1038/s41590-021-00967-5.Peer-Reviewed Original ResearchSignal-transducing innate receptors in tumor immunity.
Hangai S, Kimura Y, Taniguchi T, Yanai H. Signal-transducing innate receptors in tumor immunity. Cancer Sci 2021, 112: 2578-2591. PMID: 33570784, DOI: 10.1111/cas.14848.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways.
Kimura Y, Negishi H, Matsuda A, Endo N, Hangai S, Inoue A, Nishio J, Taniguchi T, Yanai H. Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways. Cancer Sci 2018, 109: 2687-2696. PMID: 29981256, DOI: 10.1111/cas.13726.Peer-Reviewed Original ResearchRevisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice.
Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T. Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Proc Natl Acad Sci U S A 2018, 115: 5253-5258. PMID: 29712834, DOI: 10.1073/pnas.1803936115.Peer-Reviewed Original Research
2017
Innate immune receptors in the regulation of tumor immunity
Hangai S, Kimura Y, Taniguchi T, Yanai H. Innate immune receptors in the regulation of tumor immunity. Oncoimmunology: A Practical Guide for Cancer Immunotherapy 2017; 407-427.Chapters
2016
The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.
Kimura Y, Inoue A, Hangai S, Saijo S, Negishi H, Nishio J, Yamasaki S, Iwakura Y, Yanai H, Taniguchi T. The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis. Proc Natl Acad Sci U S A 2016, 113: 14097-14102. PMID: 27872290, DOI: 10.1073/pnas.1617903113.Peer-Reviewed Original ResearchIL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.
Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y. IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression. Cancer Sci 2016, 107: 1206-14. PMID: 27384869, DOI: 10.1111/cas.13005.Peer-Reviewed Original ResearchPGE2 induced in and released by dying cells functions as an inhibitory DAMP.
Hangai S, Ao T, Kimura Y, Matsuki K, Kawamura T, Negishi H, Nishio J, Kodama T, Taniguchi T, Yanai H. PGE2 induced in and released by dying cells functions as an inhibitory DAMP. Proc Natl Acad Sci U S A 2016, 113: 3844-9. PMID: 27001836, DOI: 10.1073/pnas.1602023113.Peer-Reviewed Original Research
2014
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses. Elife 2014, 3: e04177. PMID: 25149452, DOI: 10.7554/eLife.04177.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Teaching & Mentoring
Get In Touch
Contacts
Mailing Address
Immunobiology
300 Cedar Street, TAC S640
New Haven, Connecticut 06520-8011
United States