Mediation analysis in longitudinal study with high-dimensional methylation mediators
Cui Y, Lin Q, Yuan X, Jiang F, Ma S, Yu Z. Mediation analysis in longitudinal study with high-dimensional methylation mediators. Briefings In Bioinformatics 2024, 25: bbae496. PMID: 39406521, PMCID: PMC11479716, DOI: 10.1093/bib/bbae496.Peer-Reviewed Original ResearchConceptsBody mass indexMediation analysisPaternal body mass indexGeneralized estimating equationsLinear mixed-effects modelsCohort dataMass indexMixed-effects modelsDNA methylation sitesHigh-dimensional mediation analysisLongitudinal studyBonferroni correctionAccurate parameter estimatesSobel testVariable selectionLongitudinal dataSimulation studyIndependence screeningMethylation sitesCpG sitesIndirect effectsParameter estimationLinearization methodHypothesis testing
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