The fetal origins of metabolic health: exploring the association between newborn biological age and metabolism hormones in childhood
Jia Z, Qiu F, He Y, Chen H, Yang C, Liu H, Zheng T, Xu S, Wang S, Li Y. The fetal origins of metabolic health: exploring the association between newborn biological age and metabolism hormones in childhood. BMC Medicine 2024, 22: 429. PMID: 39379967, PMCID: PMC11462715, DOI: 10.1186/s12916-024-03629-z.Peer-Reviewed Original ResearchConceptsRestricted cubic splinesLeptin levelsMetabolic hormonesMetabolic healthDNA methylationRestricted cubic spline analysisProspective birth cohort studyDNA methylation ageMother-child pairsBirth cohort studyDNA copy numberFetal originMitochondrial DNA copy numberResultsThe linear regression analysisReal-time PCRCohort studyHorvath's epigenetic clockInsulin levelsInverse associationLeptinQuantitative real-time PCRInfinium MethylationEPIC BeadChipElectrochemiluminescence assayLinear regression analysisMetabolic status
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