2022
Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry
Shou B, Ong C, Premraj L, Brown P, Tonna J, Dalton H, Kim B, Keller S, Whitman G, Cho S. Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry. The Journal Of Heart And Lung Transplantation 2022, 42: 503-511. PMID: 36435686, PMCID: PMC10050131, DOI: 10.1016/j.healun.2022.10.019.Peer-Reviewed Original ResearchConceptsAcute brain injuryExtracorporeal Life Support Organization registrySevere hyperoxiaIschemic strokeIntracranial hemorrhageECPR patientsArterial oxygenBrain injuryLarge international multicenter cohortMultivariable logistic regression analysisExtracorporeal cardiopulmonary resuscitation patientsInternational multicenter cohortSignificant risk factorsBlood gas dataBlood gas parametersCardiopulmonary resuscitation patientsLogistic regression analysisCarbon dioxide tensionHospital mortalityMild hypercarbiaMulticenter cohortReperfusion injuryMultivariable analysisResuscitation patientsRisk factorsArterial Carbon Dioxide and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation
Shou BL, Ong CS, Zhou AL, Al-Kawaz MN, Etchill E, Giuliano K, Dong J, Bush E, Kim BS, Choi CW, Whitman G, Cho SM. Arterial Carbon Dioxide and Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2022, 68: 1501-1507. PMID: 35671442, PMCID: PMC9477972, DOI: 10.1097/mat.0000000000001699.Peer-Reviewed Original ResearchConceptsAcute brain injuryVenoarterial extracorporeal membrane oxygenationExtracorporeal membrane oxygenationPaCO 2Blood gas dataIntracranial hemorrhageBrain injuryMembrane oxygenationHypoxic-ischemic brain injuryArterial blood gas dataUnivariable logistic regression analysisArterial carbon dioxide tensionTertiary care centerVA-ECMO patientsArterial carbon dioxidePaCO 2 valuesLogistic regression analysisCarbon dioxide tensionPrevalence of ICHVA-ECMOAdult patientsCerebral edemaIschemic strokeCare centerBrain death
2021
Neuromonitoring detects brain injury in patients receiving extracorporeal membrane oxygenation support
Ong CS, Etchill E, Dong J, Shou BL, Shelley L, Giuliano K, Al-Kawaz M, Ritzl EK, Geocadin RG, Kim BS, Bush EL, Choi CW, Whitman GJR, Cho SM. Neuromonitoring detects brain injury in patients receiving extracorporeal membrane oxygenation support. Journal Of Thoracic And Cardiovascular Surgery 2021, 165: 2104-2110.e1. PMID: 34865837, DOI: 10.1016/j.jtcvs.2021.09.063.Peer-Reviewed Original ResearchConceptsAcute brain injuryExtracorporeal membrane oxygenationMultivariable logistic regressionEra 2Neurological outcomeECMO patientsBrain injuryEra 1Pre-ECMO cardiac arrestUnderwent extracorporeal membrane oxygenationExtracorporeal membrane oxygenation supportLogistic regressionImproved neurological outcomeSerial neurological examinationsGood neurological outcomeMembrane oxygenation supportProportion of patientsTranscranial Doppler ultrasoundOxygenation supportMembrane oxygenationNeurological examinationCare consultationsCardiac arrestMultimodal neuromonitoringPatient outcomesFactors Related to Survival in Low–Glomerular Filtration Rate Cohorts Undergoing Lung Transplant
Funamoto M, Osho AA, Li SS, Moonsamy P, Mohan N, Ong CS, Melnitchouk S, Sundt TM, Astor TL, Villavicencio MA. Factors Related to Survival in Low–Glomerular Filtration Rate Cohorts Undergoing Lung Transplant. The Annals Of Thoracic Surgery 2021, 112: 1797-1804. PMID: 33421391, DOI: 10.1016/j.athoracsur.2020.12.021.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateLung transplantationImproved survivalPreoperative glomerular filtration rateML/minNormal glomerular filtration rateLung transplant listingOrgan Sharing databaseLogistic regression analysisLung recipientsTransplant listingLung transplantAdult patientsPropensity matchingSharing databaseOutpatient statusUnited NetworkKaplan-MeierFiltration rateSuperior survivalPropensity score methodsPatientsTransplantationMultivariate analysisOutpatient recipients
2020
Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality
Asher SR, Malzberg GW, Ong CS, Malapero RJ, Wang H, Shekar P, Kaneko T, Pelletier MP, Mallidi H, Heydarpour M, Shook DC, Shernan SK, Fox JA, Muehlschlegel JD, Xu X, Nguyen TB, Sundt TM, Body SC. Joint preoperative transthoracic and intraoperative transoesophageal echocardiographic assessment of functional mitral regurgitation severity provides better association with long-term mortality. Interdisciplinary CardioVascular And Thoracic Surgery 2020, 32: 9-19. PMID: 33313764, PMCID: PMC8600023, DOI: 10.1093/icvts/ivaa230.Peer-Reviewed Original ResearchConceptsFunctional mitral regurgitationAortic valve replacementModerate mitral regurgitationMitral regurgitationMR severityPostoperative mortalityPreoperative transthoracicValve replacementEchocardiographic assessmentLong-term postoperative mortalityAortic valve replacement surgerySeverity of MRCoronary artery bypassLong-term mortalityValve replacement surgeryInduction of anesthesiaIschemic heart diseaseAortic valve diseaseProportional hazards regressionMitral valve repairPrediction of mortalityFunctional mitral regurgitation severityMitral regurgitation severityIntraoperative reassessmentArtery bypassAssociation of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia
Crow JR, Nam L, Chasler JE, Ong CS, Dane KE, Kickler T, Lawton J, Streiff MB, Alejo D, Canner JK, Schena S. Association of Heparin Dose, Route, Timing, and Duration With Heparin-Induced Thrombocytopenia. The Annals Of Thoracic Surgery 2020, 112: 32-37. PMID: 33217393, DOI: 10.1016/j.athoracsur.2020.09.033.Peer-Reviewed Original ResearchConceptsCardiac surgery patientsAdult cardiac surgery patientsSurgery patientsUFH doseHeparin doseRetrospective case-control studyMultivariable conditional logistic regressionCardiopulmonary bypass durationHIT-positive patientsPrevalence of heparinUnfractionated heparin doseHeparin-Induced ThrombocytopeniaReceiver-operating characteristic curveCase-control studyConditional logistic regressionBypass durationIntravenous UFHUFH administrationUFH infusionSubcutaneous routeContinuous infusionMean agePatientsTotal doseLogistic regressionThe Strongest Risk Factor for Operative Mortality in Acute Type A Aortic Dissection is Acidosis: Validation of Risk Model
Ong CS, Nam L, Yesantharao P, Dong J, Canner JK, Teuben RJ, Zhou X, Young A, Suarez-Pierre A, Pasque MK, Lawton JS. The Strongest Risk Factor for Operative Mortality in Acute Type A Aortic Dissection is Acidosis: Validation of Risk Model. Seminars In Thoracic And Cardiovascular Surgery 2020, 32: 674-680. PMID: 32105786, DOI: 10.1053/j.semtcvs.2020.02.023.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAcidosisAcute DiseaseAdolescentAdultAgedAged, 80 and overAlgorithmsAortic AneurysmAortic DissectionDecision Support TechniquesFemaleHemodynamicsHospital MortalityHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTreatment OutcomeVascular Surgical ProceduresYoung AdultConceptsHigh operative mortalityOperative mortalityMultivariable logistic regressionSevere acidosisATAAD repairOrgan malperfusionAortic dissectionBase deficitRisk factorsAcute Type A Aortic DissectionType A Aortic DissectionLogistic regressionA Aortic DissectionPresence of diabetesRetrospective chart reviewMultiple risk factorsAbdominal malperfusionNadir pHAcute typeChart reviewTreatment algorithmAdvanced ageMalperfusionPatientsAcidosis
2019
Pulmonary Arterial Elastance and INTERMACS-Defined Right Heart Failure Following Left Ventricular Assist Device
Muslem R, Ong C, Tomashitis B, Schultz J, Ramu B, Craig M, Van Bakel A, Gilotra N, Sharma K, Hsu S, Whitman G, Leary P, Cogswell R, Lozonschi L, Houston B, Zijlstra F, Caliskan K, Bogers A, Tedford R. Pulmonary Arterial Elastance and INTERMACS-Defined Right Heart Failure Following Left Ventricular Assist Device. Circulation Heart Failure 2019, 12: e005923. PMID: 31401840, DOI: 10.1161/circheartfailure.119.005923.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedCardiac CatheterizationEchocardiographyElasticityFemaleHeart FailureHeart VentriclesHeart-Assist DevicesHumansMaleMiddle AgedPostoperative ComplicationsPulmonary ArteryRegistriesRetrospective StudiesStroke VolumeSurvival RateUnited StatesVascular ResistanceVentricular Function, RightConceptsSevere acute right heart failureAcute right heart failureRight heart failureSystolic pulmonary artery pressurePulmonary artery pressureVentricular assist device implantationPulmonary arterial elastanceAssist device implantationRight atrial pressureArtery pressureVentricular assist deviceAtrial pressureHeart failureArterial elastanceDevice implantationAssist deviceSevere right heart failureIndependent hazard ratioStrongest hemodynamic predictorRight heart catheterizationLarge academic centerDevice survival ratesPreimplant variablesCause mortalityHeart catheterizationA Century of Heparin
Ong CS, Marcum JA, Zehr KJ, Cameron DE. A Century of Heparin. The Annals Of Thoracic Surgery 2019, 108: 955-958. PMID: 31077659, DOI: 10.1016/j.athoracsur.2019.03.104.Peer-Reviewed Original Research
2017
Heart Failure Is Common and Under-Recognized in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Gilotra NA, Bhonsale A, James CA, Te Riele ASJ, Murray B, Tichnell C, Sawant A, Ong CS, Judge DP, Russell SD, Calkins H, Tedford RJ. Heart Failure Is Common and Under-Recognized in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia. Circulation Heart Failure 2017, 10: e003819. PMID: 28874384, DOI: 10.1161/circheartfailure.116.003819.Peer-Reviewed Original ResearchConceptsPrecordial T-wave inversionTask Force criteriaT-wave inversionHF signsExertional dyspneaLV dysfunctionVolume overloadClinical HFVentricular cardiomyopathy/dysplasiaPredictors of HFSymptomatic LV dysfunctionHeart failure prevalenceForce criteriaARVC/DARVC/D.ARVC/D diagnosisHeart transplantationHF symptomsRV involvementHeart failureStudy cohortFemale sexHF onsetHigher oddsStudy followVirtual Surgery for Conduit Reconstruction of the Right Ventricular Outflow Tract
Ong CS, Loke YH, Opfermann J, Olivieri L, Vricella L, Krieger A, Hibino N. Virtual Surgery for Conduit Reconstruction of the Right Ventricular Outflow Tract. World Journal For Pediatric And Congenital Heart Surgery 2017, 8: 391-393. PMID: 28520540, PMCID: PMC5695863, DOI: 10.1177/2150135117692777.Peer-Reviewed Original ResearchConceptsRight ventricular outflow tractVentricular outflow tractCardiac surgeryOutflow tractPulmonary artery conduit replacementTranscatheter pulmonary valve implantationRV-PA conduitPulmonary valve implantationIndividual patient dataHistory of tetralogyPatient's own heartConduit sizeVirtual surgeryImplantation of prosthesesConduit replacementImplantation of devicesPreoperative magnetic resonance imaging (MRI) dataPulmonary atresiaYoung adolescent malesValve implantationConduit reconstructionIntrathoracic spaceRight ventricleMagnetic resonance imaging dataPatient education
2016
Constrictive Pericarditis Following Correction of Partial Anomalous Pulmonary Venous Drainage
Ong CS, Shankar S, Yip JWL, Tay ELW, Teo LLS, Quek SC. Constrictive Pericarditis Following Correction of Partial Anomalous Pulmonary Venous Drainage. World Journal For Pediatric And Congenital Heart Surgery 2016, 8: 540-542. PMID: 27647341, DOI: 10.1177/2150135116652116.Peer-Reviewed Original ResearchConceptsConstrictive pericarditisPartial anomalous pulmonary venous drainagePartial anomalous pulmonary venous connectionPersistent right heart failureAnomalous pulmonary venous connectionAnomalous pulmonary venous drainagePulmonary valve replacementRight heart failurePulmonary venous connectionPulmonary venous drainageRepair of tetralogyFailure of surgeryCongenital cardiac surgeryMagnetic resonance imagingRadical pericardiectomyResidual complicationsValve replacementVenous connectionCardiac surgeryHeart failureCardiac failureMedical managementVenous drainageBetter outcomesResonance imaging
2010
Prevalence of limited cancer knowledge in Singaporeans, its determinants and association with cancer screening
Ong CS, Ooi G, Tan XQ, Lee J, Koh GC, Verkooijen HM. Prevalence of limited cancer knowledge in Singaporeans, its determinants and association with cancer screening. Preventive Medicine 2010, 50: 304-305. PMID: 20211644, DOI: 10.1016/j.ypmed.2010.02.013.Peer-Reviewed Original Research
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