Albert C Shaw, MD, PhD
Professor of Medicine (Infectious Diseases)DownloadHi-Res Photo
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Professor of Medicine (Infectious Diseases)
Biography
Dr. Shaw is a graduate of Harvard College who completed his M.D. training at Harvard Medical School and his Ph.D. in the laboratory of Philip Leder. After completing his clinical training in Internal Medicine and Infectious Diseases at Massachusetts General Hospital, he was a postdoctoral fellow in the laboratory of Fred Alt. Dr. Shaw joined the faculty at Yale in 2001, and is currently Professor of Medicine in the Section of Infectious Diseases. His research focuses on the immunology of aging, and his laboratory has interests in age-associated alterations in innate immune function and vaccine response in humans, as well as circadian regulation of immune response and mechanisms of inflammatory dysregulation in medication-associated treatment of opioid use disorder. He was a Howard Hughes Postdoctoral Physician Research Fellow, Brookdale National Fellow, and T. Franklin Williams Scholar, and he is a Fellow of the Infectious Disease Society of America and member of the Interurban Clinical Club.
Last Updated on April 07, 2025.
Appointments
Infectious Diseases
ProfessorPrimary
Other Departments & Organizations
- All Institutions
- Center for Infection and Immunity
- Claude D. Pepper Older Americans Independence Center
- CPIRT - Center for Pulmonary Injury, Inflammation, Repair and Therapeutics
- Human and Translational Immunology Program
- Infectious Diseases
- Internal Medicine
- Rheumatic Diseases Research Core
- Yale Center for Research on Aging (Y-Age)
- Yale Medicine
- Yale New Haven Health System
- Yale Ventures
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative
Education & Training
- Fellow
- Massachusetts General Hospital (1997)
- Fellowship
- Massachusetts General Hospital (1996)
- Intern and Resident
- Massachusetts General Hospital (1994)
- Residency
- Massachusetts General Hospital (1994)
- PhD
- Harvard University (1991)
- MD
- Harvard Medical School (1991)
- AB
- Harvard College (1983)
Research
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Overview
Medical Research Interests
Aging; DNA Repair; Immune System; Immunity, Innate; Infectious Disease Medicine; Influenza Vaccines; Toll-Like Receptors
ORCID
0000-0003-4970-7640
Research at a Glance
Yale Co-Authors
Frequent collaborators of Albert C Shaw's published research.
Publications Timeline
A big-picture view of Albert C Shaw's research output by year.
Research Interests
Research topics Albert C Shaw is interested in exploring.
Ruth R Montgomery, PhD
Steven Kleinstein, PhD
Akiko Iwasaki, PhD
Albert Ko, MD
David A. Hafler, MD, FANA, MSc
Nathan Grubaugh, PhD
66Publications
8,306Citations
Aging
Immunity, Innate
Influenza Vaccines
Toll-Like Receptors
Immune System
Publications
2025
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
Mishra M, Kim HH, Youm YH, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw AC, Scherer PE, Artyomov MN, Dixit VD. Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. BioRxiv 2025 PMID: 40799539, DOI: 10.1101/2025.08.04.668533.Publications for non-academic audiencesMicrofluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes
Sewall L, de Paiva Froes Rocha R, Gibson G, Louie M, Xie Z, Bangaru S, Tran A, Ozorowski G, Mohanty S, Beutler N, Rogers T, Burton D, Shaw A, Batista F, Chocarro Ruiz B, Torrents de la Peña A, Ward A. Microfluidics combined with electron microscopy for rapid and high-throughput mapping of antibody–viral glycoprotein complexes. Nature Biomedical Engineering 2025, 1-14. PMID: 40461656, DOI: 10.1038/s41551-025-01411-x.Peer-Reviewed Original ResearchAltmetricConceptsStructure-based vaccine designVolumes of seraHA glycoproteinPolyclonal antibodiesImmune complexesAntibody responseVaccine designVaccine developmentHigh-throughput mappingCharacterization of immune complexesVaccinated individualsAntibodiesGlycoprotein complexViral glycoproteinsInvading pathogensEpitope mappingSeraSingle-particle electron microscopyGlycoproteinNegative-stain electron microscopyHormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.
Guan C, Ryu S, Dong M, Youm YH, Mohanty S, Maeda R, Orliaguet L, Kim HH, Dlugos T, Smith SR, Ravussin E, Onyuru J, Wang A, Shaw AC, Hoffman HM, Kluger Y, Sugiura Y, Dixit VD. Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome. BioRxiv 2025 PMID: 40501605, DOI: 10.1101/2025.05.27.656381.Publications for non-academic audiencesHigh affinity CD16 polymorphism associated with reduced risk of severe COVID-19
Qualls A, Tsao T, Lui I, Lim S, Su Y, Chen E, Duchen D, Maecker H, Kim-Schulze S, Montgomery R, Krammer F, Langelier C, Levy O, Baden L, Melamed E, Ehrlich L, McComsey G, Sekaly R, Cairns C, Haddad E, Shaw A, Hafler D, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Pulendran B, Nadeau K, Davis M, Fernandez-Sesma A, Simon V, Kraft M, Bime C, Calfee C, Erle D, Schaenmann J, Ozonoff A, Peters B, Kleinstein S, Augustine A, Diray-Arce J, Becker P, Rouphael N, Network I, Goldman J, Calabrese D, Heath J, Wells J, Reed E, Lanier L, Pickering H, Aguilar O. High affinity CD16 polymorphism associated with reduced risk of severe COVID-19. JCI Insight 2025 PMID: 40402577, DOI: 10.1172/jci.insight.191314.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAntibody-dependent cellular cytotoxicitySevere COVID-19Anti-SARS-CoV-2 IgG titersNK cell-mediated immune responsesNK cell-mediated antibody-dependent cellular cytotoxicityHost-directed therapeutic strategiesSevere disease trajectoryCell-mediated immune responsesHospitalized COVID-19 patientsLevels of inflammatory mediatorsNatural killer cellsSevere respiratory complicationsImmunopathogenesis of COVID-19Activating Fc receptorsRisk of ICU admissionRisk of severe COVID-19SARS-CoV-2 infectionCOVID-19 patientsCOVID-19 cohortIn vitro reporter systemKiller cellsRespiratory complicationsCellular cytotoxicityViral loadImmunophenotypic assessmentHost-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
Pickering H, Schaenman J, Phan H, Maguire C, Tsitsiklis A, Rouphael N, Higuita N, Atkinson M, Brakenridge S, Fung M, Messer W, Salehi-rad R, Altman M, Becker P, Bosinger S, Eckalbar W, Hoch A, Doni Jayavelu N, Kim-Schulze S, Jenkins M, Kleinstein S, Krammer F, Maecker H, Ozonoff A, Diray-Arce J, Shaw A, Baden L, Levy O, Reed E, Langelier C. Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients. Nature Communications 2025, 16: 586. PMID: 39794319, PMCID: PMC11723965, DOI: 10.1038/s41467-025-55823-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSolid organ transplant recipientsOrgan transplant recipientsTransplant recipientsInduction of pro-inflammatory genesSenescent T cellsTransitional B cellsImpaired viral clearanceImmune response to infectionAnti-spike IgG levelsNon-transplanted controlsFeatures of COVID-19Innate Immune Signaling PathwaysResponse to infectionPro-inflammatory genesSerum chemokinesViral clearanceImmune dysregulationT cellsImmune signaling pathwaysB cellsImmune featuresSex-matchedIgG levelsSevere diseaseTransplantation
2024
The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity
Marin-Lopez A, Huck J, Esterly A, Azcutia V, Rosen C, Garcia-Milian R, Sefik E, Vidal-Pedrola G, Raduwan H, Chen T, Arora G, Halene S, Shaw A, Palm N, Flavell R, Parkos C, Thangamani S, Ring A, Fikrig E. The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity. Science Immunology 2024, 9: eadk9872-eadk9872. PMID: 39121194, PMCID: PMC11924945, DOI: 10.1126/sciimmunol.adk9872.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSuppress antiviral responsesArthropod proteinsPathogen replicationAntiviral responseProtein AVertebrate hostsMosquito salivary proteinsUp-regulatedBlood feedingHuman macrophagesPleomorphic effectsSkin infectionsZika virus disseminationInhibit proinflammatory responsesSalivary proteinsProteinNatural ligandWhite blood cellsHuman skin explantsProinflammatory responseMosquito salivaVirus disseminationHuman CD47Salivary factorsArbovirus infectionIgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
Ozonoff A, Ehrlich L, Melamed E, Sesma A, Simon V, Pulendran B, Nadeau K, Davis M, McCoey G, Sekaly R, Baden L, Levy O, Schaenman J, Reed E, Shaw A, Hafler D, Montgomery R, Kleinstein S, Becker P, Augustine A, Calfee C, Erle D, DeBakey M, Corry D, Kheradmand F, Atkinson M, Brakenridge S, Higuita N, Metcalf J, Hough C, Messer W, Kraft M, Bime C, Peters B, Milliren C, Syphurs C, McEnaney K, Barton B, Lentucci C, Saluvan M, Chang A, Hoch A, Albert M, Shaheen T, Kho A, Liu S, Thomas S, Chen J, Murphy M, Cooney M, Hayati A, Bryant R, Abraham J, Jayavelu N, Presnell S, Jancsyk T, Maguire C, Qi J, Lee B, Fourati S, Esserman D, Guan L, Gygi J, Pawar S, Brito A, Fragiadakis G, Patel R, Overton J, Vita R, Westendorf K, Shannon C, Tebbutt S, Thyagarajan R, Rousseau J, Wylie D, Triplett T, Kojic E, Chinthrajah S, Ahuja N, Rogers A, Artandi M, Geng L, Yendewa G, Powell D, Kim J, Simmons B, Goonewardene I, Smith C, Martens M, Sherman A, Walsh S, Issa N, Salehi-Rad R, Dela Cruz C, Farhadian S, Iwasaki A, Ko A, Anderson E, Mehta A, Sevransky J, Seyfert-Margolis V, Leligdowicz A, Matthay M, Singer J, Kangelaris K, Hendrickson C, Krummel M, Langelier C, Woodruff P, Corry D, Kheradmand F, Anderson M, Guirgis F, Drevets D, Brown B, Siegel S, Lu Z, Mosier J, Kimura H, Khor B, van Bakel H, Rahman A, Stadlbauer D, Dutta J, Xie H, Kim-Schulze S, Gonzalez-Reiche A, van de Guchte A, Carreño J, Singh G, Raskin A, Tcheou J, Bielak D, Kawabata H, Kelly G, Patel M, Nie K, Yellin T, Fried M, Sullivan L, Morris S, Sieg S, Steen H, van Zalm P, Fatou B, Mendez K, Lasky-Su J, Hutton S, Michelotti G, Wong K, Jha M, Viode A, Kanarek N, Petrova B, Zhao Y, Bosinger S, Boddapati A, Tharp G, Pellegrini K, Beagle E, Cowan D, Hamilton S, Ribeiro S, Hodder T, Rosen L, Lee S, Wilson M, Dandekar R, Alvarenga B, Rajan J, Eckalbar W, Schroeder A, Tsitsiklis A, Mick E, Guerrero Y, Love C, Maliskova L, Adkisson M, Siles N, Geltman J, Hurley K, Saksena M, Altman D, Srivastava K, Eaker L, Bermúdez-González M, Beach K, Sominsky L, Azad A, Mulder L, Kleiner G, Lee A, Do E, Fernandes A, Manohar M, Hagan T, Blish C, Din H, Roque J, Yang S, Sigal N, Chang I, Tribout H, Harris P, Consolo M, Edwards C, Lee E, Lin E, Croen B, Semenza N, Rogowski B, Melnyk N, Bell M, Furukawa S, McLin R, Schearer P, Sheidy J, Tegos G, Nagle C, Smolen K, Desjardins M, van Haren S, Mitre X, Cauley J, Li X, Tong A, Evans B, Montesano C, Licona J, Krauss J, Chang J, Izaguirre N, Rooks R, Elashoff D, Brook J, Ramires-Sanchez E, Llamas M, Rivera A, Perdomo C, Ward D, Magyar C, Fulcher J, Pickering H, Sen S, Chaudhary O, Coppi A, Fournier J, Mohanty S, Muenker C, Nelson A, Raddassi K, Rainone M, Ruff W, Salahuddin S, Schulz W, Vijayakumar P, Wang H, Wunder E, Young H, Rothman J, Konstorum A, Chen E, Cotsapas C, Grubaugh N, Wang X, Xu L, Asashima H, Bristow L, Hussaini L, Hellmeister K, Samaha H, Wimalasena S, Cheng A, Spainhour C, Scherer E, Johnson B, Bechnak A, Ciric C, Hewitt L, Carter E, Mcnair N, Panganiban B, Huerta C, Usher J, Vaysman T, Holland S, Abe-Jones Y, Asthana S, Beagle A, Bhide S, Carrillo S, Chak S, Ghale R, Gonzalez A, Jauregui A, Jones N, Lea T, Lee D, Lota R, Milush J, Nguyen V, Pierce L, Prasad P, Rao A, Samad B, Shaw C, Sigman A, Sinha P, Ward A, Willmore A, Zhan J, Rashid S, Rodriguez N, Tang K, Altamirano L, Betancourt L, Curiel C, Sutter N, Paz M, Tietje-Ulrich G, Leroux C, Thakur N, Vasquez J, Santhosh L, Song L, Nelson E, Moldawer L, Borresen B, Roth-Manning B, Ungaro R, Oberhaus J, Booth J, Sinko L, Brunton A, Sullivan P, Strnad M, Lyski Z, Coulter F, Micheleti C, Conway M, Francisco D, Molzahn A, Erickson H, Wilson C, Schunk R, Sierra B, Hughes T. IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition. Nature Communications 2024, 15: 404. PMID: 38195739, PMCID: PMC10776791, DOI: 10.1038/s41467-023-44211-0.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective
Leng S, Shaw A. Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective. Immunity & Ageing 2023, 20: 69. PMID: 38031077, PMCID: PMC10685665, DOI: 10.1186/s12979-023-00392-2.Peer-Reviewed Original ResearchCitationsAltmetricPrior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination
Asashima H, Kim D, Wang K, Lele N, Buitrago-Pocasangre N, Lutz R, Cruz I, Raddassi K, Ruff W, Racke M, Wilson J, Givens T, Grifoni A, Weiskopf D, Sette A, Kleinstein S, Montgomery R, Shaw A, Li F, Fan R, Hafler D, Tomayko M, Longbrake E. Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination. JCI Insight 2023, 8: e168102. PMID: 37606046, PMCID: PMC10543713, DOI: 10.1172/jci.insight.168102.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSARS-CoV-2 mRNA vaccinationB-cell-depleted patientsB-cell depletionAntibody responseMRNA vaccinationThird doseCell depletionT cellsClaude D. Pepper Older Americans Independence CenterB cellsNational Multiple Sclerosis SocietyAnti-CD20 antibodySpike-specific antibodiesMultiple Sclerosis SocietyLow cumulative exposureLogistic regression modelsImportant clinical needCD20 therapyCD20 treatmentMost patientsThird vaccineSerologic responseVaccine dosesMRNA vaccinesVaccination strategiesIncreasing sensitivity of antibody-antigen interactions using photo-cross-linking
de la Peña A, Sewall L, de Paiva Froes Rocha R, Jackson A, Pratap P, Bangaru S, Cottrell C, Mohanty S, Shaw A, Ward A. Increasing sensitivity of antibody-antigen interactions using photo-cross-linking. Cell Reports Methods 2023, 3: 100509. PMID: 37426749, PMCID: PMC10326447, DOI: 10.1016/j.crmeth.2023.100509.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPolyclonal immune responseImmune responseTime pointsRational vaccine designLater time pointsEarly time pointsVaccine immunogensAnimal modelsAntibody detectionVaccine designIntermediate antibodiesEarly timepointsLater timepointsAntibodiesViral glycoproteinsTimepointsDifferent viral glycoproteinsSensitivity of detectionAntibody-antigen interactionsResponsePatientsVaccination
Clinical Trials
Current Trials
Immune Response Analysis in Lymph Node Tissue
HIC ID2000032631RoleSub InvestigatorPrimary Completion Date04/30/2027Recruiting ParticipantsEffects of circadian regulation and sleep on immune responses
HIC ID2000027037RolePrincipal InvestigatorPrimary Completion Date02/28/2025Recruiting ParticipantsGenderBothAge21+ yearsImpact of HIV Infection on Immunologic, Transcriptomic, and Metabolomic Signatures
HIC ID1608018239RoleSub InvestigatorPrimary Completion Date09/01/2021Recruiting ParticipantsGenderBothAge18+ years
Clinical Care
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Overview
Albert C. Shaw, MD, PhD, is an infectious diseases specialist who provides care for individuals with a variety of infections, including those that affect older adults. He focuses on how age-related changes in the body’s defenses can make people more vulnerable to infection and immune system complications.
As a professor of medicine at Yale School of Medicine, Dr. Shaw studies the ways in which the immune system’s first line of defense, called the innate immune system, changes with age. This includes investigating how these shifts might reduce vaccine effectiveness and contribute to ongoing, low-grade inflammation that can harm overall health. He also examines how circadian rhythms—biological processes that follow a 24-hour cycle—may regulate immune responses, as well as how certain treatments for opioid use disorder might influence inflammation.
Dr. Shaw earned his medical degree from Harvard Medical School and completed a doctorate at Harvard University. He then pursued an internal medicine residency and an infectious diseases fellowship at Massachusetts General Hospital.
Clinical Specialties
Infectious Diseases
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Influenza (Flu)
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- August 27, 2025
Yale Pepper Center Seeks Letters of Intent For Aging Research 2025 - 2026
- February 19, 2025Source: MSN
Is Now the Time to Really Worry About Bird Flu?
- November 19, 2024Source: Yahoo
What are the symptoms of foodborne illnesses like E. coli? What to know amid a new carrot recall.
- September 27, 2024Source: WTNH
Health headlines: Why you shouldn’t put off the shingles vaccine
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