The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights from Type II Diabetes
Hebda JA, Miranker AD. The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights from Type II Diabetes. Annual Review Of Biophysics 2009, 38: 125-152. PMID: 19416063, DOI: 10.1146/annurev.biophys.050708.133622.Peer-Reviewed Original ResearchConceptsAmyloid fibersLipid bilayersAlpha-helical stateAmyloid intermediatesProtein foldingBeta-sheet formationDevelopment of therapeuticsBiological functionsProtein precursorIntermediate speciesMolecular levelIonic homeostasisClass of diseasesFibrillar stateMature fibersType II diabetesCatalysisSpeciesCytotoxic speciesIntermediatesAffected tissuesII diabetesBilayersPrecursorsRecent advances
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