Anthony Enzo Seddio, MD
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Semaglutide utilization associated with reduced 90-day postoperative complications following single-level posterior lumbar fusion for patients with type II diabetes
Seddio A, Gouzoulis M, Vasudevan R, Dhodapkar M, Jabbouri S, Varthi A, Rubio D, Grauer J. Semaglutide utilization associated with reduced 90-day postoperative complications following single-level posterior lumbar fusion for patients with type II diabetes. The Spine Journal 2024, 25: 485-493. PMID: 39491749, DOI: 10.1016/j.spinee.2024.10.011.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSodium-glucose transport protein 2 inhibitorsAdverse eventsPostoperative complicationsT2DM patientsCurrent Procedural TerminologyElixhauser Comorbidity IndexED visitsLumbar fusionHospital readmissionEmergency departmentOdds of postoperative complicationsNinety-day postoperative complicationsImpact of semaglutideOdds of hospital readmissionMonths of surgeryRetrospective cohort studyPostoperative adverse eventsMinor adverse eventsType II diabetes mellitusRisk of type I errorDiagnosis of T2DMII diabetes mellitusYears of agePredictors of Venous Thromboembolism Following Geriatric Distal Femur Fracture Fixation: Are These Patients at Higher Risk Compared With Hip Fracture Patients?
Seddio A, Vasudevan R, Gouzoulis M, Jabbouri S, Grauer J, Fram B. Predictors of Venous Thromboembolism Following Geriatric Distal Femur Fracture Fixation: Are These Patients at Higher Risk Compared With Hip Fracture Patients? JAAOS Global Research And Reviews 2025, 9: e24.00246. PMID: 39823200, PMCID: PMC11745856, DOI: 10.5435/jaaosglobal-d-24-00246.Peer-Reviewed Original ResearchConceptsOdds of venous thromboembolismDirect oral anticoagulantsVenous thromboembolismHeightened oddsHFx patientsIncreased odds of VTEPredictors of venous thromboembolismRisk factors of venous thromboembolismIncidence of venous thromboembolismRate of venous thromboembolismAssociated with considerable morbidityAssociated with reduced oddsFactors of venous thromboembolismEffective therapeutic optionIndependent risk factorClinical risk factorsHip fracture patientsRetrospective cohort studyFemur fracture fixationCoagulopathy disordersOral anticoagulantsElixhauser Comorbidity IndexSurgical managementActive cancerDistal femur fracture fixationComparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections: An Analysis of 1.29 Million Patients.
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Vasudevan R, Day W, Ratnasamy P, Rubio D, Grauer J. Comparable Overall Risk of Neurologic Adverse Events Following Cervicothoracic Interlaminar and Transforaminal Epidural Injections: An Analysis of 1.29 Million Patients. Spine 2024 PMID: 39394649, DOI: 10.1097/brs.0000000000005181.Peer-Reviewed Original ResearchNeurological adverse eventsAdverse eventsElixhauser Comorbidity IndexNeurological complicationsOdds ratioEpidural spinal injectionsInterlaminar (ILTransforaminal epidural injectionsAssociated with specific complicationsTransforaminal (TFNerve root injuryRisk of complicationsAssociated with higher odds ratiosMultivariate logistic regressionRisk of neurological adverse eventsHigher odds ratioCervical pathologyEpidural hematomaTF injectionSpinal injectionEpidural injectionSpecific complicationsAdult patientsCase reportComorbidity indexLower Risk of Postoperative Complications and Rotator Cuff Retear Associated With Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair
Seddio A, Moran J, Gouzoulis M, Garbis N, Salazar D, Grauer J, Jimenez A. Lower Risk of Postoperative Complications and Rotator Cuff Retear Associated With Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2024, 41: 199-206. PMID: 39490542, DOI: 10.1016/j.arthro.2024.09.057.Peer-Reviewed Original ResearchArthroscopic rotator cuff repairT2DM patientsRotator cuff retearRotator cuff repairElixhauser Comorbidity IndexAdverse eventsLow risk of postoperative complicationsOdds ratioRisk of postoperative complicationsKaplan-Meier survival analysisUrinary tract infectionSurgical-site infectionCuff repairLog-rank testRetrospective comparative studyAcute kidney injuryMinor adverse eventsType II diabetes mellitusAssociated with decreased oddsMultivariate logistic regressionArthroscopic shoulder proceduresII diabetes mellitusAdministrative billing codesPostoperative complicationsTract infectionsRobotic-Assisted Versus Navigation-Assisted Posterior Lumbar Fusion
Gouzoulis M, Seddio A, Winter A, Jabbouri S, Zhu J, Rubio D, Varthi A, Grauer J. Robotic-Assisted Versus Navigation-Assisted Posterior Lumbar Fusion. Spine 2024, 49: 1483-1487. PMID: 38717329, DOI: 10.1097/brs.0000000000005032.Peer-Reviewed Original ResearchPosterior lumbar fusionLumbar fusionAdverse eventsLevel posterior lumbar fusionsCPT codesKaplan-Meier survival analysisRate of reoperationNavigation-assisted surgeryRobotic-assisted casesNavigation-assistedMinor adverse eventsPerioperative adverse eventsMultivariate logistic regressionICD-10 procedure codeRobotic cohortRobotic assistanceSpinal navigationReoperation rateAnterior fusionElixhauser Comorbidity IndexPearlDiver databaseNo significant differenceIncremental advantageAdverse outcomesComorbidity index
2025
As Few as Three Months of Preoperative Semaglutide Exposure Prior to Total Knee Arthroplasty Is Associated With Reduced Postoperative Adverse Events in Patients With Type II Diabetes.
Seddio AE, Vasudevan RS, Gouzoulis MJ, Ansah-Twum JK, Grauer JN, Rubin LE. As Few as Three Months of Preoperative Semaglutide Exposure Prior to Total Knee Arthroplasty Is Associated With Reduced Postoperative Adverse Events in Patients With Type II Diabetes. J Arthroplasty 2025 PMID: 40784425, DOI: 10.1016/j.arth.2025.08.003.Peer-Reviewed Original ResearchObesity Correlates With 90-Day Postoperative Complications but Not 5-Year Retearing Rates After Anterior Cruciate Ligament Reconstruction.
Ajjawi I, Seddio AE, Grauer JN. Obesity Correlates With 90-Day Postoperative Complications but Not 5-Year Retearing Rates After Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med 2025, 13: 23259671251358378. PMID: 40727238, DOI: 10.1177/23259671251358378.Peer-Reviewed Original ResearchReduced 90-Day Cardiovascular and Infectious Complications After Open Reduction Internal Fixation of Ankle Fractures in Type II Diabetic Patients Using Semaglutide Preoperatively.
Seddio A, Vasudevan R, Jonnalagadda A, Slevin J, Grauer J, Fram B. Reduced 90-Day Cardiovascular and Infectious Complications After Open Reduction Internal Fixation of Ankle Fractures in Type II Diabetic Patients Using Semaglutide Preoperatively. Journal Of The American Academy Of Orthopaedic Surgeons 2025 PMID: 40549942, DOI: 10.5435/jaaos-d-25-00439.Peer-Reviewed Original ResearchAnkle fracture ORIFAnkle fracturesInfectious complicationsPostoperative outcomesElixhauser Comorbidity IndexReduction internal fixation of ankle fracturesComorbidity indexInternal fixation of ankle fracturesORIF of ankle fracturesFixation of ankle fracturesDays of follow-upSodium-glucose cotransporter 2 inhibitor useOpen reduction internal fixationHigh-energy injury mechanismsType II diabetic patientsUrinary tract infectionInferior postoperative outcomesSurgical site infectionDeep vein thrombosisType II diabetes mellitusMultivariate logistic regressionII diabetes mellitusElective orthopaedic surgeryTibial plafond fracturesTract infectionsPredictors of Physical, Chiropractic, and Acupuncture Therapy Utilization in the Three Months Following Newly Diagnosed Low Back Pain.
Seddio A, Dhodapkar M, Halperin S, Jabbouri S, Gouzoulis M, Joo P, Grauer J. Predictors of Physical, Chiropractic, and Acupuncture Therapy Utilization in the Three Months Following Newly Diagnosed Low Back Pain. Clinical Spine Surgery A Spine Publication 2025 PMID: 40521727, DOI: 10.1097/bsd.0000000000001859.Peer-Reviewed Original ResearchLow back painChiropractic therapyAcupuncture therapyBack painDays of low back painNonclinical factorsLow back pain patientsPredictors of CT utilizationTherapy utilizationMultivariate logistic regressionMusculoskeletal problemsPhysical therapyElixhauser Comorbidity IndexIndependent predictorsLogistic regressionCT utilizationUtilization patternsAcupunctureLevel IIIMale sexExclusion criteriaComorbidity indexTherapy typeNational levelPainThe incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury
Seddio A, Jabbouri S, Vasudevan R, Gouzoulis M, Day W, Maloy G, Varthi A, Rubio D, Grauer J. The incidence and trends of diving-related spine injuries in the United States and risk factors associated with spinal cord injury. Spinal Cord 2025, 1-7. PMID: 40490487, DOI: 10.1038/s41393-025-01098-6.Peer-Reviewed Original ResearchEstimated annual percentage changeSpine injuriesSpinal cord injuryRisk factorsLumbar spineInjury prevention programsAnnual percentage changePublic health initiativesCord injuryCervical spine surgeryMultivariate logistic regressionLog-linear regressionUnique risk factorsHealth initiativesUnited StatesCervical spondylolisthesisElixhauser Comorbidity IndexCervical spinePrevention programsAdministrative datasetsLogistic regressionSpine surgeryPercentage changeCervical stenosisOlder age