Carolina Maciel, MD
About
Research
Publications
2024
Early vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus
Maciel C, Ahmad B, Jose Bruzzone Giraldez M, Eisenschenk S, Ramsay E, Maranchick N, Peloquin C, Hirsch L, Busl K. Early vigabatrin to augment GABAergic pathways in post-anoxic status epilepticus. Epilepsy & Behavior 2024, 160: 110082. PMID: 39393141, DOI: 10.1016/j.yebeh.2024.110082.Peer-Reviewed Original ResearchStatus epilepticusGamma-aminobutyric acidGABAergic pathwayHypoxic-ischemic brain injuryPost-cardiac arrest periodHypoxic-ischemic insultOutcomes of patientsEffective adjunctive therapyInhibition of gamma-aminobutyric acidLondon-Innsbruck ColloquiumAdjunctive therapyAcute seizuresEffective therapyPoor outcomeEpilepticusExclusion criteriaEarly inhibitionSynergistic augmentationGamma-aminobutyric acid catabolismArrest periodTherapeutic nihilismSeizuresClinal trialsAllosteric modulatorsVigabatrinCyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury
Comparan H, Khaliq A, Frota L, Pomar-Forero D, Ahmad B, Marnet E, Teixeira F, Thomas A, Patel P, Brunkal H, Singireddy S, Lucke-Wold B, Maciel C, Busl K. Cyclooxygenase 2 Inhibitors for Headache After Elective Cranial Neurosurgery: Results from a Systematic Review of Efficacy of Cyclooxygenase 2 Inhibitors for Headache After Acute Brain Injury. Neurocritical Care 2024, 1-10. PMID: 39266865, DOI: 10.1007/s12028-024-02114-y.Peer-Reviewed Original ResearchIntervention groupSystematic reviewHeadache managementCyclooxygenase 2 inhibitorsAcute brain injuryElective cranial neurosurgeryPain scoresRandomized controlled trialsHospital length of stayRetrospective cohort studyLength of stayModerate to mild severityBrain injuryIndependent reviewersDescriptive statisticsCohort studyStudy heterogeneityInclusion criteriaControlled trialsArticle selectionObservational studyInterventionMeta-analysisElective cranial surgeryHospital lengthRationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design
Busl K, Smith C, Troxel A, Fava M, Illenberger N, Pop R, Yang W, Frota L, Gao H, Shan G, Hoh B, Maciel C. Rationale and Design for the BLOCK-SAH Study (Pterygopalatine Fossa Block as an Opioid-Sparing Treatment for Acute Headache in Aneurysmal Subarachnoid Hemorrhage): A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Clinical Trial with a Sequential Parallel Comparison Design. Neurocritical Care 2024, 1-11. PMID: 39138719, DOI: 10.1007/s12028-024-02078-z.Peer-Reviewed Original ResearchSequential parallel comparison designDouble-blindPain controlPterygopalatine fossaClinical trialsPlacebo-Controlled Clinical TrialPrimary tolerability end pointEnd pointsVerbal pain scoresEfficacy end pointOpen-label phaseTolerability end pointsPhase III trialsPost-subarachnoid hemorrhagePhase IIIII trialsPain scoresAcute headacheAneurysmal SAHSevere headachePeriprocedural monitoringPost-SAHHeadache phenotypeUltrasound guidanceAwake patientsLeveraging machine learning to develop a postoperative predictive model for postoperative urinary retention following lumbar spine surgery
Malnik S, Porche K, Mehkri Y, Yue S, Maciel C, Lucke-Wold B, Robicsek S, Decker M, Busl K. Leveraging machine learning to develop a postoperative predictive model for postoperative urinary retention following lumbar spine surgery. Frontiers In Neurology 2024, 15: 1386802. PMID: 38988605, PMCID: PMC11233696, DOI: 10.3389/fneur.2024.1386802.Peer-Reviewed Original ResearchPostoperative urinary retentionLumbar spine surgerySpine surgeryUrinary retentionPatient demographicsIncidence of postoperative urinary retentionRetrospective observational cohort studyTertiary academic medical centerIndwelling catheter placementIncreased patient morbidityReceiver operating characteristic curveArea under the receiver operating characteristic curveObservational cohort studyAcademic medical centerBody mass indexPostoperative prediction modelLogistic regression modelsIntraoperative variablesIntraoperative factorsCatheter placementAnesthesia variablesPatient morbidityMass indexSurgical proceduresCohort studyNeuro-oncologic Emergencies
Maciel C, Busl K. Neuro-oncologic Emergencies. CONTINUUM Lifelong Learning In Neurology 2024, 30: 845-877. PMID: 38830073, DOI: 10.1212/con.0000000000001435.Peer-Reviewed Original ResearchConceptsNeuro-oncologic emergenciesNeurological complicationsCentral nervous system malignanciesPrimary central nervous system malignancySystemic disease progressionTumor-specific characteristicsAcute neurologic complicationsNervous system malignanciesTreatment-resistant seizuresCSF flow dynamicsIntracranial burdenTumor-mediatedBrain metastasesImmunological therapiesNeuronal hyperexcitabilitySystem malignanciesTumor-relatedNeurotoxicity syndromeIntracranial hypertensionRisk stratificationFavorable outcomeTreatment-relatedSystem cancersDisease progressionComplicationsVerification of Death by Neurologic Criteria: A Survey of 12 Organ Procurement Organizations Across the United States
Sarhadi K, Hendershot K, Smith N, Souter M, Creutzfeldt C, Lele A, Maciel C, Busl K, Balogh J, Greer D, Lewis A, Wahlster S. Verification of Death by Neurologic Criteria: A Survey of 12 Organ Procurement Organizations Across the United States. Neurocritical Care 2024, 41: 847-854. PMID: 38750393, DOI: 10.1007/s12028-024-02001-6.Peer-Reviewed Original ResearchOrgan procurement organizationsClinician knowledgeBackgroundThe Centers for MedicareReferral hospitalGuideline-concordant practicesAmerican AcademyCenters for MedicareMethodsAn electronic surveyMedical society guidelinesUnited StatesProcurement organizationsVerification of deathDetermine validityHospital policiesPractice parametersElectronic surveyAmerican Academy of Neurology practice parameterFederal lawAdvocacy effortsLegal requirementsReferralUS regionsPotential organ donorsNeurological CriteriaPublic trustA Spectrum, Not a Dichotomy for Seizure Foretelling—Learning to Identify Ominous Patterns and Understand the Pediatric Ictal-Interictal Continuum
Kincaid K, Maciel C. A Spectrum, Not a Dichotomy for Seizure Foretelling—Learning to Identify Ominous Patterns and Understand the Pediatric Ictal-Interictal Continuum. Neurocritical Care 2024, 41: 326-327. PMID: 38671314, DOI: 10.1007/s12028-024-01991-7.Peer-Reviewed Original ResearchSurvey of Nationwide Organ Procurement Organization (OPO) Practices in Verification of Death by Neurologic Criteria (DNC) (P1-2.001)
Sarhadi K, Hendershot K, Smith N, Souter M, Creutzfeldt C, Lele A, Maciel C, Balogh J, Greer D, Busl K, Lewis A, Wahlster S. Survey of Nationwide Organ Procurement Organization (OPO) Practices in Verification of Death by Neurologic Criteria (DNC) (P1-2.001). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205433.Peer-Reviewed Original ResearchEfficacy of Cyclooxygenase-2 Inhibitors for Headache in Acute Brain Injury: A Systematic Review (P7-12.006)
Frota L, Khaliq A, Comparan H, Pomar-Forero D, Ahmad B, Maciel C, Busl K. Efficacy of Cyclooxygenase-2 Inhibitors for Headache in Acute Brain Injury: A Systematic Review (P7-12.006). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206229.Peer-Reviewed Original ResearchVIGAB-STAT—A Phase IIa Feasibility Trial of Irreversible GABA-transaminase Inhibition as Adjunct Treatment of Status Epilepticus After Cardiac Arrest (P4-2.003)
Ahmad B, Maranchick N, Pomar-Forero D, Busl K, Hirsch L, Bruzzone M, Eisenschenk S, Peloquin C, Maciel C. VIGAB-STAT—A Phase IIa Feasibility Trial of Irreversible GABA-transaminase Inhibition as Adjunct Treatment of Status Epilepticus After Cardiac Arrest (P4-2.003). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205180.Peer-Reviewed Original Research