Charles Kenworthy, MD, PhD
Clinical FellowDownloadHi-Res Photo
About
Titles
Clinical Fellow
Appointments
Medical Oncology and Hematology
Clinical FellowPrimary
Other Departments & Organizations
- ABIM Physician-Scientist Research Pathway
- All Institutions
- Halene Lab
- Internal Medicine
- Medical Oncology and Hematology
Education & Training
- PhD
- Albert Einstein College of Medicine (2020)
- MD
- Albert Einstein College of Medicine (2020)
- BA
- University of Pennsylvania, Biology (2010)
Research
Research at a Glance
Publications Timeline
A big-picture view of Charles Kenworthy's research output by year.
7Publications
8Citations
Publications
2022
Bromodomains regulate dynamic targeting of the PBAF chromatin-remodeling complex to chromatin hubs
Kenworthy C, Haque N, Liou S, Chandris P, Wong V, Dziuba P, Lavis L, Liu W, Singer R, Coleman R. Bromodomains regulate dynamic targeting of the PBAF chromatin-remodeling complex to chromatin hubs. Biophysical Journal 2022, 121: 1738-1752. PMID: 35364106, PMCID: PMC9117891, DOI: 10.1016/j.bpj.2022.03.027.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsChromatin remodelersChromatin statePBAF chromatin-remodeling complexSingle-molecule fluorescence microscopy studiesDifferent chromatin statesChromatin-remodeling complexRNA polymerase IIChromatin hubTranscriptional burstingPolymerase IIAcetylated nucleosomesFluorescence microscopy studiesPBAFBromodomainsNucleosomesChromatin stabilityLive cellsStable engagementRemodelersDynamic targetingDirect roleChromatinImaging revealsTargetingGenome
2018
Single Molecule Imaging of Chromatin Remodeling in Live Cells
Kenworthy C, Wong V, Dziuba P, Lavis L, Liu W, Singer R, Coleman R. Single Molecule Imaging of Chromatin Remodeling in Live Cells. Biophysical Journal 2018, 114: 536a. DOI: 10.1016/j.bpj.2017.11.2929.Peer-Reviewed Original Research
2017
Dual Inhibition of Mdmx and Mdm2 Using an Alpha-Helical P53 Stapled Peptide (ALRN-6924) As a Novel Therapeutic Strategy in Acute Myeloid Leukemia
Carvajal L, Ben-Neriah D, Senecal A, Bernard L, Narayanagari S, Kenworthy C, Thiruthuvanathan V, Guerlavais V, Annis D, Bartholdy B, Will B, Anampa J, Mantzaris I, Aivado M, Singer R, Coleman R, Verma A, Steidl U. Dual Inhibition of Mdmx and Mdm2 Using an Alpha-Helical P53 Stapled Peptide (ALRN-6924) As a Novel Therapeutic Strategy in Acute Myeloid Leukemia. Blood 2017, 130: 795. DOI: 10.1182/blood.v130.suppl_1.795.795.Peer-Reviewed Original ResearchConceptsAML cell linesAML patient cellsAML cellsMDM2 inhibitionHealthy controlsLeukemic stemCell linesAge-matched healthy controlsWild-type p53Significant improved survivalProgenitor cellsAML xenograft modelStem cell-enriched populationAnti-leukemic effectsPatient cellsPatient undergoing treatmentAcute myeloid leukemiaCellular proliferationNovel therapeutic strategiesCell-enriched populationsTarget gene p21Primary cellsTP53 tumor suppressor geneObjective responseImproved survivalSoutheast and East Asian American Medical Students’ Perceptions of Careers in Academic Medicine
Zhang L, Lee E, Kenworthy C, Chiang S, Holaday L, Spencer D, Poll-Hunter N, Sánchez J. Southeast and East Asian American Medical Students’ Perceptions of Careers in Academic Medicine. Journal Of Career Development 2017, 46: 235-250. DOI: 10.1177/0894845317740225.Peer-Reviewed Original ResearchConceptsCommunity-engaged researchRacial groupsMedical students' perceptionsAsian communitiesGreater inclusionLargest racial groupAcademic medicine careersQualitative dataStudents' perceptionsCareer discussionsRole modelsUnited StatesRole models/mentorsHealth care issuesPerceptionSuch interventionsCareerMedical studentsMedicine careersCommunication skillsContent developmentServicesAsiansAcademic medicineLeadershipImaging Transcription Dynamics in Single Cancer Cells
Senecal A, Kenworthy C, Lavis L, Liu W, Singer R, Coleman R. Imaging Transcription Dynamics in Single Cancer Cells. Biophysical Journal 2017, 112: 211a. DOI: 10.1016/j.bpj.2016.11.1166.Peer-Reviewed Original Research
2016
Single Molecule Imaging of p53's Dynamic Interaction with Chromatin
Wong V, Liu Z, Peng S, Kenworthy C, Liu W, Coleman R. Single Molecule Imaging of p53's Dynamic Interaction with Chromatin. Biophysical Journal 2016, 110: 516a. DOI: 10.1016/j.bpj.2015.11.2758.Peer-Reviewed Original Research
2014
Single Molecule Probing of P53's Ability to Dynamically Regulate Chromatin Structure
Wong V, Chen Y, Kenworthy C, Song L, Dailey G, Liu W, Coleman R. Single Molecule Probing of P53's Ability to Dynamically Regulate Chromatin Structure. Biophysical Journal 2014, 106: 485a. DOI: 10.1016/j.bpj.2013.11.4463.Peer-Reviewed Original Research